Genetic variants associated with sleep disorders

Highlights • Patients undergoing polysomnography consented to research use of clinical data. • DNA was genotyped from saliva samples. • Peroxisome proliferator-activated receptor gamma, coactivator 1 beta ( PPARGC1B ) rs6888451 was associated with several markers of obstructive apnea. • Aryl hydroca...

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Bibliographic Details
Published in:Sleep medicine 2015-02, Vol.16 (2), p.217-224
Main Authors: Kripke, Daniel F, Kline, Lawrence E, Nievergelt, Caroline M, Murray, Sarah S, Shadan, Farhad F, Dawson, Arthur, Poceta, J. Steven, Cronin, John, Jamil, Shazia M, Tranah, Gregory J, Loving, Richard T, Grizas, Alexandra P, Hahn, Elizabeth K
Format: Article
Language:English
Subjects:
Adult
ARNTL Transcription Factors - genetics
ARNTL Transcription Factors - physiology
Carrier Proteins - genetics
Carrier Proteins - physiology
Casein Kinase II - genetics
Casein Kinase II - physiology
Cryptochromes - genetics
Cryptochromes - physiology
DIMS
Female
Genetic Association Studies
Humans
Male
Nerve Tissue Proteins
Neurology
Nocturnal Myoclonus Syndrome - genetics
Nuclear Receptor Subfamily 1, Group F, Member 1 - genetics
Nuclear Receptor Subfamily 1, Group F, Member 1 - physiology
Oligonucleotide Array Sequence Analysis
Polymorphism, Single Nucleotide - genetics
Polymorphism, Single Nucleotide - physiology
Polysomnography
PPARGC1B
RNA-Binding Proteins
rs10766071
rs3923809
Sleep apnea
Sleep Apnea, Obstructive - genetics
Sleep Medicine
Sleep Wake Disorders - genetics
Sleep-related periodic leg movements
Transcription Factors - genetics
Transcription Factors - physiology
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Summary:Highlights • Patients undergoing polysomnography consented to research use of clinical data. • DNA was genotyped from saliva samples. • Peroxisome proliferator-activated receptor gamma, coactivator 1 beta ( PPARGC1B ) rs6888451 was associated with several markers of obstructive apnea. • Aryl hydrocarbon receptor nuclear translocator-like ( ARNTL ) rs10766071 was associated with decreased polysomnographic sleep duration. • BTBD9 rs3823798 was associated with periodic limb movements but not restless legs.
ISSN:1389-9457
1878-5506
DOI:10.1016/j.sleep.2014.11.003