Encapsulation of Curcumin in Diblock Copolymer Micelles for Cancer Therapy

Application of nanoparticles has recently promising results for water insoluble agents like curcumin. In this study, we synthesized polymeric nanoparticle-curcumin (PNPC) and then showed its efficiency, drug loading, stability, and safety. Therapeutic effects of PNPC were also assessed on two cell l...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-14
Main Authors: Khodayari, Hamid, Mohagheghi, Mohammad Ali, Khodayari, Saeed, Rezaei, Arezou, Khaniki, Mahmood, Erfani-Moghadam, Vahid, Ardestani, Sussan K., Najafi, Farhood, Sadeghizadeh, Majid, Alizadeh, Ali Mohammad, Zamani, Mina
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Apoptosis - drug effects
Block copolymers
Breast cancer
Breast Neoplasms - drug therapy
Cancer
Carcinoma, Hepatocellular - drug therapy
Care and treatment
Cell Line
Cell Line, Tumor
Cell Proliferation - drug effects
Curcumin - administration & dosage
Drug Carriers - administration & dosage
Drug delivery systems
Drug Stability
Female
Humans
Liver Neoplasms - drug therapy
Medical research
Mice
Mice, Inbred BALB C
Micelles
Nanoparticles - administration & dosage
Polyethylene glycol
Polymers - administration & dosage
Production processes
Turmeric
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c528t-f592e2d8cbc954b58ee339e1865599e160eb8128b148431dbb315d8c242caf453
cites cdi_FETCH-LOGICAL-c528t-f592e2d8cbc954b58ee339e1865599e160eb8128b148431dbb315d8c242caf453
container_end_page 14
container_issue 2015
container_start_page 1
container_title BioMed research international
container_volume 2015
creator Khodayari, Hamid
Mohagheghi, Mohammad Ali
Khodayari, Saeed
Rezaei, Arezou
Khaniki, Mahmood
Erfani-Moghadam, Vahid
Ardestani, Sussan K.
Najafi, Farhood
Sadeghizadeh, Majid
Alizadeh, Ali Mohammad
Zamani, Mina
description Application of nanoparticles has recently promising results for water insoluble agents like curcumin. In this study, we synthesized polymeric nanoparticle-curcumin (PNPC) and then showed its efficiency, drug loading, stability, and safety. Therapeutic effects of PNPC were also assessed on two cell lines and in an animal model of breast cancer. PNPC remarkably suppressed mammary and hepatocellular carcinoma cells proliferation ( P < 0.05 ). Under the dosing procedure, PNPC was safe at 31.25 mg/kg and lower doses. Higher doses demonstrated minimal hepatocellular and renal toxicity in paraclinical and histopathological examinations. Tumor take rate in PNPC-treated group was 37.5% compared with 87.5% in control ( P < 0.05 ). Average tumor size and weight were significantly lower in PNPC group than control ( P < 0.05 ). PNPC increased proapoptotic Bax protein expression ( P < 0.05 ). Antiapoptotic Bcl-2 protein expression, however, was lower in PNPC-treated animals than the control ones ( P < 0.05 ). In addition, proliferative and angiogenic parameters were statistically decreased in PNPC-treated animals ( P < 0.05 ). These results highlight the suppressing role for PNPC in in vitro and in vivo tumor growth models. Our findings provide credible evidence for superior biocompatibility of the polymeric nanocarrier in pharmacological arena together with an excellent tumor-suppressing response.
doi_str_mv 10.1155/2015/824746
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4352453</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A458163466</galeid><sourcerecordid>A458163466</sourcerecordid><originalsourceid>FETCH-LOGICAL-c528t-f592e2d8cbc954b58ee339e1865599e160eb8128b148431dbb315d8c242caf453</originalsourceid><addsrcrecordid>eNqNkUFv1DAQhSNERau2J-4oEhdUtG3G9nidC1IVChQVcSlny_FOui6JHewNaP89jrYshVMtS2PZ3zx53iuKl1CdAyBesArwQjGxFPJZccQ4iIUEAc_3Z84Pi9OU7qu8FMiqli-KQ4bLmrNKHRWfr7w1Y5p6s3HBl6ErmynaaXC-zPu9a_tgv5dNGEO_HSiWX5ylvqdUdiGWjfE2392uKZpxe1IcdKZPdPpQj4tvH65um0-Lm68fr5vLm4VFpjaLDmtGbKVsa2sULSoizmsCJRHrXGVFrQKmWhBKcFi1LQfMOBPMmk4gPy7e7XTHqR1oZclvoun1GN1g4lYH4_S_L96t9V34qQVHlvuzwJsHgRh-TJQ2enBpHst4ClPSIJeSo8oGPQGVCAyFWGb09X_ofZiiz07MFHBgAthf6s70pJ3vQv6inUX1pcAcEBdSZurtjrIxpBSp208HlZ5z13Puepd7pl89NmTP_kk5A2c7YO38yvxyT1OjjFBnHsEolQL-G9XPu74</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1661312412</pqid></control><display><type>article</type><title>Encapsulation of Curcumin in Diblock Copolymer Micelles for Cancer Therapy</title><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>Wiley-Blackwell Titles (Open access)</source><creator>Khodayari, Hamid ; Mohagheghi, Mohammad Ali ; Khodayari, Saeed ; Rezaei, Arezou ; Khaniki, Mahmood ; Erfani-Moghadam, Vahid ; Ardestani, Sussan K. ; Najafi, Farhood ; Sadeghizadeh, Majid ; Alizadeh, Ali Mohammad ; Zamani, Mina</creator><contributor>Cavalcanti, Bruno C.</contributor><creatorcontrib>Khodayari, Hamid ; Mohagheghi, Mohammad Ali ; Khodayari, Saeed ; Rezaei, Arezou ; Khaniki, Mahmood ; Erfani-Moghadam, Vahid ; Ardestani, Sussan K. ; Najafi, Farhood ; Sadeghizadeh, Majid ; Alizadeh, Ali Mohammad ; Zamani, Mina ; Cavalcanti, Bruno C.</creatorcontrib><description><![CDATA[Application of nanoparticles has recently promising results for water insoluble agents like curcumin. In this study, we synthesized polymeric nanoparticle-curcumin (PNPC) and then showed its efficiency, drug loading, stability, and safety. Therapeutic effects of PNPC were also assessed on two cell lines and in an animal model of breast cancer. PNPC remarkably suppressed mammary and hepatocellular carcinoma cells proliferation ( P < 0.05 ). Under the dosing procedure, PNPC was safe at 31.25 mg/kg and lower doses. Higher doses demonstrated minimal hepatocellular and renal toxicity in paraclinical and histopathological examinations. Tumor take rate in PNPC-treated group was 37.5% compared with 87.5% in control ( P < 0.05 ). Average tumor size and weight were significantly lower in PNPC group than control ( P < 0.05 ). PNPC increased proapoptotic Bax protein expression ( P < 0.05 ). Antiapoptotic Bcl-2 protein expression, however, was lower in PNPC-treated animals than the control ones ( P < 0.05 ). In addition, proliferative and angiogenic parameters were statistically decreased in PNPC-treated animals ( P < 0.05 ). These results highlight the suppressing role for PNPC in in vitro and in vivo tumor growth models. Our findings provide credible evidence for superior biocompatibility of the polymeric nanocarrier in pharmacological arena together with an excellent tumor-suppressing response.]]></description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2015/824746</identifier><identifier>PMID: 25793208</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Animals ; Antineoplastic Agents - administration &amp; dosage ; Apoptosis - drug effects ; Block copolymers ; Breast cancer ; Breast Neoplasms - drug therapy ; Cancer ; Carcinoma, Hepatocellular - drug therapy ; Care and treatment ; Cell Line ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Curcumin - administration &amp; dosage ; Drug Carriers - administration &amp; dosage ; Drug delivery systems ; Drug Stability ; Female ; Humans ; Liver Neoplasms - drug therapy ; Medical research ; Mice ; Mice, Inbred BALB C ; Micelles ; Nanoparticles - administration &amp; dosage ; Polyethylene glycol ; Polymers - administration &amp; dosage ; Production processes ; Turmeric</subject><ispartof>BioMed research international, 2015-01, Vol.2015 (2015), p.1-14</ispartof><rights>Copyright © 2015 Ali Mohammad Alizadeh et al.</rights><rights>COPYRIGHT 2015 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2015 Ali Mohammad Alizadeh et al. Ali Mohammad Alizadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2015 Ali Mohammad Alizadeh et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-f592e2d8cbc954b58ee339e1865599e160eb8128b148431dbb315d8c242caf453</citedby><cites>FETCH-LOGICAL-c528t-f592e2d8cbc954b58ee339e1865599e160eb8128b148431dbb315d8c242caf453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1661312412/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1661312412?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25751,27922,27923,37010,37011,44588,74896</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25793208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Cavalcanti, Bruno C.</contributor><creatorcontrib>Khodayari, Hamid</creatorcontrib><creatorcontrib>Mohagheghi, Mohammad Ali</creatorcontrib><creatorcontrib>Khodayari, Saeed</creatorcontrib><creatorcontrib>Rezaei, Arezou</creatorcontrib><creatorcontrib>Khaniki, Mahmood</creatorcontrib><creatorcontrib>Erfani-Moghadam, Vahid</creatorcontrib><creatorcontrib>Ardestani, Sussan K.</creatorcontrib><creatorcontrib>Najafi, Farhood</creatorcontrib><creatorcontrib>Sadeghizadeh, Majid</creatorcontrib><creatorcontrib>Alizadeh, Ali Mohammad</creatorcontrib><creatorcontrib>Zamani, Mina</creatorcontrib><title>Encapsulation of Curcumin in Diblock Copolymer Micelles for Cancer Therapy</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description><![CDATA[Application of nanoparticles has recently promising results for water insoluble agents like curcumin. In this study, we synthesized polymeric nanoparticle-curcumin (PNPC) and then showed its efficiency, drug loading, stability, and safety. Therapeutic effects of PNPC were also assessed on two cell lines and in an animal model of breast cancer. PNPC remarkably suppressed mammary and hepatocellular carcinoma cells proliferation ( P < 0.05 ). Under the dosing procedure, PNPC was safe at 31.25 mg/kg and lower doses. Higher doses demonstrated minimal hepatocellular and renal toxicity in paraclinical and histopathological examinations. Tumor take rate in PNPC-treated group was 37.5% compared with 87.5% in control ( P < 0.05 ). Average tumor size and weight were significantly lower in PNPC group than control ( P < 0.05 ). PNPC increased proapoptotic Bax protein expression ( P < 0.05 ). Antiapoptotic Bcl-2 protein expression, however, was lower in PNPC-treated animals than the control ones ( P < 0.05 ). In addition, proliferative and angiogenic parameters were statistically decreased in PNPC-treated animals ( P < 0.05 ). These results highlight the suppressing role for PNPC in in vitro and in vivo tumor growth models. Our findings provide credible evidence for superior biocompatibility of the polymeric nanocarrier in pharmacological arena together with an excellent tumor-suppressing response.]]></description><subject>Animals</subject><subject>Antineoplastic Agents - administration &amp; dosage</subject><subject>Apoptosis - drug effects</subject><subject>Block copolymers</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Cancer</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Care and treatment</subject><subject>Cell Line</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Curcumin - administration &amp; dosage</subject><subject>Drug Carriers - administration &amp; dosage</subject><subject>Drug delivery systems</subject><subject>Drug Stability</subject><subject>Female</subject><subject>Humans</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Medical research</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Micelles</subject><subject>Nanoparticles - administration &amp; dosage</subject><subject>Polyethylene glycol</subject><subject>Polymers - administration &amp; dosage</subject><subject>Production processes</subject><subject>Turmeric</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqNkUFv1DAQhSNERau2J-4oEhdUtG3G9nidC1IVChQVcSlny_FOui6JHewNaP89jrYshVMtS2PZ3zx53iuKl1CdAyBesArwQjGxFPJZccQ4iIUEAc_3Z84Pi9OU7qu8FMiqli-KQ4bLmrNKHRWfr7w1Y5p6s3HBl6ErmynaaXC-zPu9a_tgv5dNGEO_HSiWX5ylvqdUdiGWjfE2392uKZpxe1IcdKZPdPpQj4tvH65um0-Lm68fr5vLm4VFpjaLDmtGbKVsa2sULSoizmsCJRHrXGVFrQKmWhBKcFi1LQfMOBPMmk4gPy7e7XTHqR1oZclvoun1GN1g4lYH4_S_L96t9V34qQVHlvuzwJsHgRh-TJQ2enBpHst4ClPSIJeSo8oGPQGVCAyFWGb09X_ofZiiz07MFHBgAthf6s70pJ3vQv6inUX1pcAcEBdSZurtjrIxpBSp208HlZ5z13Puepd7pl89NmTP_kk5A2c7YO38yvxyT1OjjFBnHsEolQL-G9XPu74</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Khodayari, Hamid</creator><creator>Mohagheghi, Mohammad Ali</creator><creator>Khodayari, Saeed</creator><creator>Rezaei, Arezou</creator><creator>Khaniki, Mahmood</creator><creator>Erfani-Moghadam, Vahid</creator><creator>Ardestani, Sussan K.</creator><creator>Najafi, Farhood</creator><creator>Sadeghizadeh, Majid</creator><creator>Alizadeh, Ali Mohammad</creator><creator>Zamani, Mina</creator><general>Hindawi Publishing Corporation</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Encapsulation of Curcumin in Diblock Copolymer Micelles for Cancer Therapy</title><author>Khodayari, Hamid ; Mohagheghi, Mohammad Ali ; Khodayari, Saeed ; Rezaei, Arezou ; Khaniki, Mahmood ; Erfani-Moghadam, Vahid ; Ardestani, Sussan K. ; Najafi, Farhood ; Sadeghizadeh, Majid ; Alizadeh, Ali Mohammad ; Zamani, Mina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-f592e2d8cbc954b58ee339e1865599e160eb8128b148431dbb315d8c242caf453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - administration &amp; dosage</topic><topic>Apoptosis - drug effects</topic><topic>Block copolymers</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Cancer</topic><topic>Carcinoma, Hepatocellular - drug therapy</topic><topic>Care and treatment</topic><topic>Cell Line</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Curcumin - administration &amp; dosage</topic><topic>Drug Carriers - administration &amp; dosage</topic><topic>Drug delivery systems</topic><topic>Drug Stability</topic><topic>Female</topic><topic>Humans</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Medical research</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Micelles</topic><topic>Nanoparticles - administration &amp; dosage</topic><topic>Polyethylene glycol</topic><topic>Polymers - administration &amp; dosage</topic><topic>Production processes</topic><topic>Turmeric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khodayari, Hamid</creatorcontrib><creatorcontrib>Mohagheghi, Mohammad Ali</creatorcontrib><creatorcontrib>Khodayari, Saeed</creatorcontrib><creatorcontrib>Rezaei, Arezou</creatorcontrib><creatorcontrib>Khaniki, Mahmood</creatorcontrib><creatorcontrib>Erfani-Moghadam, Vahid</creatorcontrib><creatorcontrib>Ardestani, Sussan K.</creatorcontrib><creatorcontrib>Najafi, Farhood</creatorcontrib><creatorcontrib>Sadeghizadeh, Majid</creatorcontrib><creatorcontrib>Alizadeh, Ali Mohammad</creatorcontrib><creatorcontrib>Zamani, Mina</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Database‎ (1962 - current)</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East &amp; Africa Database</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khodayari, Hamid</au><au>Mohagheghi, Mohammad Ali</au><au>Khodayari, Saeed</au><au>Rezaei, Arezou</au><au>Khaniki, Mahmood</au><au>Erfani-Moghadam, Vahid</au><au>Ardestani, Sussan K.</au><au>Najafi, Farhood</au><au>Sadeghizadeh, Majid</au><au>Alizadeh, Ali Mohammad</au><au>Zamani, Mina</au><au>Cavalcanti, Bruno C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Encapsulation of Curcumin in Diblock Copolymer Micelles for Cancer Therapy</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>2015</volume><issue>2015</issue><spage>1</spage><epage>14</epage><pages>1-14</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract><![CDATA[Application of nanoparticles has recently promising results for water insoluble agents like curcumin. In this study, we synthesized polymeric nanoparticle-curcumin (PNPC) and then showed its efficiency, drug loading, stability, and safety. Therapeutic effects of PNPC were also assessed on two cell lines and in an animal model of breast cancer. PNPC remarkably suppressed mammary and hepatocellular carcinoma cells proliferation ( P < 0.05 ). Under the dosing procedure, PNPC was safe at 31.25 mg/kg and lower doses. Higher doses demonstrated minimal hepatocellular and renal toxicity in paraclinical and histopathological examinations. Tumor take rate in PNPC-treated group was 37.5% compared with 87.5% in control ( P < 0.05 ). Average tumor size and weight were significantly lower in PNPC group than control ( P < 0.05 ). PNPC increased proapoptotic Bax protein expression ( P < 0.05 ). Antiapoptotic Bcl-2 protein expression, however, was lower in PNPC-treated animals than the control ones ( P < 0.05 ). In addition, proliferative and angiogenic parameters were statistically decreased in PNPC-treated animals ( P < 0.05 ). These results highlight the suppressing role for PNPC in in vitro and in vivo tumor growth models. Our findings provide credible evidence for superior biocompatibility of the polymeric nanocarrier in pharmacological arena together with an excellent tumor-suppressing response.]]></abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>25793208</pmid><doi>10.1155/2015/824746</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2314-6133
ispartof BioMed research international, 2015-01, Vol.2015 (2015), p.1-14
issn 2314-6133
2314-6141
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4352453
source Publicly Available Content Database (Proquest) (PQ_SDU_P3); Wiley-Blackwell Titles (Open access)
subjects Animals
Antineoplastic Agents - administration & dosage
Apoptosis - drug effects
Block copolymers
Breast cancer
Breast Neoplasms - drug therapy
Cancer
Carcinoma, Hepatocellular - drug therapy
Care and treatment
Cell Line
Cell Line, Tumor
Cell Proliferation - drug effects
Curcumin - administration & dosage
Drug Carriers - administration & dosage
Drug delivery systems
Drug Stability
Female
Humans
Liver Neoplasms - drug therapy
Medical research
Mice
Mice, Inbred BALB C
Micelles
Nanoparticles - administration & dosage
Polyethylene glycol
Polymers - administration & dosage
Production processes
Turmeric
title Encapsulation of Curcumin in Diblock Copolymer Micelles for Cancer Therapy
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T12%3A12%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Encapsulation%20of%20Curcumin%20in%20Diblock%20Copolymer%20Micelles%20for%20Cancer%20Therapy&rft.jtitle=BioMed%20research%20international&rft.au=Khodayari,%20Hamid&rft.date=2015-01-01&rft.volume=2015&rft.issue=2015&rft.spage=1&rft.epage=14&rft.pages=1-14&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2015/824746&rft_dat=%3Cgale_pubme%3EA458163466%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c528t-f592e2d8cbc954b58ee339e1865599e160eb8128b148431dbb315d8c242caf453%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1661312412&rft_id=info:pmid/25793208&rft_galeid=A458163466&rfr_iscdi=true