Transplantation of autologous bone marrow-derived mesenchymal stem cells for traumatic brain injury

Results from the present study demonstrated that transplantation of autologous bone marrow-derived mesenchymal stem cells into the lesion site in rat brain significantly ameliorated brain tissue pathological changes and brain edema, attenuated glial cell proliferation, and increased brain-derived ne...

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Bibliographic Details
Published in:Neural regeneration research 2012-01, Vol.7 (1), p.46-53
Main Authors: Jiang, Jindou, Bu, Xingyao, Liu, Meng, Cheng, Peixun
Format: Article
Language:English
Subjects:
Angiogenesis
Apoptosis
Bone marrow
Brain-derived neurotrophic factor
Cell growth
Edema
Growth factors
Neurogenesis
Research and Report: Stem Cells and Neuroregenration
Stem cells
Studies
Traumatic brain injury
外伤
干细胞移植
病变部位
脑源性神经营养因子
脑组织
自体
间质干细胞
骨髓
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Summary:Results from the present study demonstrated that transplantation of autologous bone marrow-derived mesenchymal stem cells into the lesion site in rat brain significantly ameliorated brain tissue pathological changes and brain edema, attenuated glial cell proliferation, and increased brain-derived neurotrophic factor expression. In addition, the number of cells double-labeled for 5-bromodeoxyuridine/glial fibrillary acidic protein and cells expressing nestin increased. Finally, blood vessels were newly generated, and the rats exhibited improved motor and cognitive functions. These results suggested that transplantation of autologous bone marrow-derived mesenchymal stem cells promoted brain remodeling and improved neurological functions following traumatic brain injury.
ISSN:1673-5374
1876-7958
DOI:10.3969/j.issn.1673-5374.2012.01.008