Sirtuin inhibitor sirtinol is an intracellular iron chelator

Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the h...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2015-03, Vol.51 (24), p.5104-5107
Main Authors: Gautam, R, Akam, E A, Astashkin, A V, Loughrey, J J, Tomat, E
Format: Article
Language:English
Subjects:
Benzamides - analysis
Benzamides - chemistry
Benzamides - pharmacology
Cell Proliferation - drug effects
Enzyme Inhibitors - analysis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Ferric Compounds - chemistry
Ferric Compounds - metabolism
Forming
Humans
Inhibitors
Intracellular Space - chemistry
Intracellular Space - drug effects
Iron
Iron Chelating Agents - analysis
Iron Chelating Agents - chemistry
Iron Chelating Agents - pharmacology
Jurkat Cells
Leukemia - metabolism
Leukemia - pathology
Leukemias
Models, Molecular
Molecular Structure
Naphthols - analysis
Naphthols - chemistry
Naphthols - pharmacology
Pools
Proteins
Sirtuins - antagonists & inhibitors
Spectroscopy
Structure-Activity Relationship
Tumor Cells, Cultured
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Summary:Sirtinol is a known inhibitor of sirtuin proteins, a family of deacetylases involved in the pathophysiology of aging. Spectroscopic and structural data reveal that this compound is also an iron chelator forming high-spin ferric species in vitro and in cultured leukemia cells. Interactions with the highly regulated iron pool therefore contribute to its overall intracellular agenda.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc00829h