Single and dual drug release patterns from shellac wax-lutrol matrix tablets fabricated with fusion and molding techniques

The objective of this investigation was to prepare the shellac wax matrix tablets by fusion and molding technique incorporated with Lutrol in different ratios to modify the hydrophobicity of matrix tablet. The matrix tablets with single drug were loaded either with propranolol hydrochloride or hydro...

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Bibliographic Details
Published in:Indian journal of pharmaceutical sciences 2015-01, Vol.77 (1), p.62-74
Main Authors: Phaechamud, T, Choncheewa, C
Format: Article
Language:English
Subjects:
Analysis
Angina pectoris
Contact angle
Copolymers
Dosage and administration
Drug dosages
Drug targeting
Drug therapy
Heart attacks
Hydrochlorothiazide
Hypertension
Methods
Pharmaceuticals
Production processes
Propranolol
R&D
Research & development
Research Paper
Standard deviation
Tablets (Pharmacy)
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Summary:The objective of this investigation was to prepare the shellac wax matrix tablets by fusion and molding technique incorporated with Lutrol in different ratios to modify the hydrophobicity of matrix tablet. The matrix tablets with single drug were loaded either with propranolol hydrochloride or hydrochlorothiazide as hydrophilic and hydrophobic model drugs, and a dual drug formula was also prepared. The single and dual drug release patterns were studied in a dissolution apparatus using distilled water as medium. Propranolol hydrochloride released from matrix was easier than hydrochlorothiazide. Drug release from shellac wax matrix could be enhanced by incorporation of Lutrol. However retardation of drug release from some matrix tablets was evident for the systems that could form dispersion in the dissolution medium. The gel network from high content of Lutrol was hexagonal which was a dense and more compact structure than the other structures found when low amounts of Lutrol were present in the formula. Therefore, the formulae with high content of Lutrol could prolong drug release more efficiently than those containing low content of Lutrol. Hence shellac wax matrix could modulate the drug release with the addition of Lutrol. Sustainable dual drug release was also obtained from these developed matrix tablets. Thus shellac wax-Lutrol component could be used as a potential matrix tablet prepared with fusion and molding technique with excellent controlled drug release.
ISSN:0250-474X
1998-3743
DOI:10.4103/0250-474X.151606