Allogeneic Versus Autologous Derived Cell Sources for Use in Engineered Bone-Ligament-Bone Grafts in Sheep Anterior Cruciate Ligament Repair

The use of autografts versus allografts for anterior cruciate ligament (ACL) reconstruction is controversial. The current popular options for ACL reconstruction are patellar tendon or hamstring autografts, yet advances in allograft technologies have made allogeneic grafts a favorable option for repa...

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Bibliographic Details
Published in:Tissue engineering. Part A 2015-03, Vol.21 (5-6), p.147-1054
Main Authors: Mahalingam, Vasudevan D., Behbahani-Nejad, Nilofar, Horine, Storm V., Olsen, Tyler J., Smietana, Michael J., Wojtys, Edward M., Wellik, Deneen M., Arruda, Ellen M., Larkin, Lisa M.
Format: Article
Language:English
Subjects:
Animals
Anterior Cruciate Ligament - surgery
Anterior Cruciate Ligament Reconstruction
Biomechanics
Bone and Bones - blood supply
Bone and Bones - innervation
Bone Transplantation
Collagen - metabolism
Elastic Modulus
Elastin - metabolism
Joint Instability
Knee Joint - pathology
Knee Joint - physiopathology
Ligaments - blood supply
Ligaments - innervation
Ligaments - transplantation
Neovascularization, Physiologic
Original
Original Articles
Sheep
Studies
Tendons
Tissue Engineering - methods
Transplantation, Autologous
Transplantation, Homologous
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Summary:The use of autografts versus allografts for anterior cruciate ligament (ACL) reconstruction is controversial. The current popular options for ACL reconstruction are patellar tendon or hamstring autografts, yet advances in allograft technologies have made allogeneic grafts a favorable option for repair tissue. Despite this, the mismatched biomechanical properties and risk of osteoarthritis resulting from the current graft technologies have prompted the investigation of new tissue sources for ACL reconstruction. Previous work by our lab has demonstrated that tissue-engineered bone-ligament-bone (BLB) constructs generated from an allogeneic cell source develop structural and functional properties similar to those of native ACL and vascular and neural structures that exceed those of autologous patellar tendon grafts. In this study, we investigated the effectiveness of our tissue-engineered ligament constructs fabricated from autologous versus allogeneic cell sources. Our preliminary results demonstrate that 6 months postimplantation, our tissue-engineered auto- and allogeneic BLB grafts show similar histological and mechanical outcomes indicating that the autologous grafts are a viable option for ACL reconstruction. These data indicate that our tissue-engineered autologous ligament graft could be used in clinical situations where immune rejection and disease transmission may preclude allograft use.
ISSN:1937-3341
1937-335X
DOI:10.1089/ten.tea.2014.0422