Expression of the γ-phosphorylated histone H2AX in gastric carcinoma and gastric precancerous lesions

The histone γH2AX is a marker of activated DNA damage that is overexpressed in various cancers and corresponding precursor lesions, indicating that γH2AX is a component in oncogenic transformation. The present study aimed to determine whether the immunohistochemical expression of γH2AX is involved i...

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Bibliographic Details
Published in:Oncology letters 2015-04, Vol.9 (4), p.1790-1794
Main Authors: GUO, ZHONG, PEI, SHUYAN, SI, TIANBIN, LI, JING, JIANG, CHAO, LI, SHANGBIAO, ZHAO, JIN
Format: Article
Language:English
Subjects:
Apoptosis
atrophic gastritis
Development and progression
DNA damage
Gastric cancer
gastric carcinoma
Gene expression
Genetic aspects
Health aspects
Histones
Kinases
Oncology
Properties
Rodents
Stomach cancer
superficial gastritis
Tumors
γH2AX
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Summary:The histone γH2AX is a marker of activated DNA damage that is overexpressed in various cancers and corresponding precursor lesions, indicating that γH2AX is a component in oncogenic transformation. The present study aimed to determine whether the immunohistochemical expression of γH2AX is involved in the progression between superficial gastritis (n=20), atrophic gastritis (n=24) and gastric carcinoma (n=79). There was no increase in γH2AX expression between superficial and atrophic gastritis, but there was a significant increase in γH2AX expression between these two conditions and gastric carcinoma (χ2=68.712; P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2015.2896