KIR2DS5 in the presence of HLA-C C2 protects against endometriosis

Endometriosis is defined as the presence of functional endometrial tissue outside the uterine cavity. Several hypotheses have attempted to explain the etiology and pathogenesis of endometriosis. Recently, it has been suggested that a defect of the natural killer (NK) activity in the recognition and...

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Bibliographic Details
Published in:Immunogenetics (New York) 2015-04, Vol.67 (4), p.203-209
Main Authors: Nowak, Izabela, Płoski, Rafał, Barcz, Ewa, Dziunycz, Piotr, Kamiński, Paweł, Kostrzewa, Grażyna, Milewski, Łukasz, Roszkowski, Piotr I., Senitzer, David, Malejczyk, Jacek, Kuśnierczyk, Piotr
Format: Article
Language:English
Subjects:
Adult
Allergology
Antigens
Biomedical and Life Sciences
Biomedicine
Cell Biology
Disease
Endometriosis
Endometriosis - epidemiology
Endometriosis - genetics
Endometriosis - immunology
Female
Fertility
Gene Frequency
Gene Function
Genetic Predisposition to Disease
Gynecology
HLA-C Antigens - genetics
Human Genetics
Humans
Hypotheses
Immunoglobulins
Immunology
Infertility
Killer Cells, Natural - immunology
Laparoscopy
Leukocytes
Ligands
Linkage Disequilibrium - genetics
Middle Aged
Obstetrics
Original Paper
Ovaries
Pathogenesis
Poland - epidemiology
Polymorphism
Receptors, KIR - genetics
Risk factors
Womens health
Young Adult
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Summary:Endometriosis is defined as the presence of functional endometrial tissue outside the uterine cavity. Several hypotheses have attempted to explain the etiology and pathogenesis of endometriosis. Recently, it has been suggested that a defect of the natural killer (NK) activity in the recognition and lysis of endometrial cells is one of the crucial points in the development of this disease. Natural killer cells can express killer immunoglobulin-like receptors (KIR), which recognize class I human leukocyte antigens on target cells. We asked whether polymorphisms in KIR , HLA-C , and HLA-B genes are risk factors for endometriosis. We tested 153 women with endometriosis diagnosed on the basis of laparoscopic and histological examination, and 213 control healthy women, who gave birth to at least one child. The frequency of KIR genes in patients was similar to that in controls except for KIR2DS5 , which exerted a protective effect only in HLA-C C2-positive individuals. Moreover, KIR2DS5- positive women with endometriosis had 13 times lower chance that the disease would occupy the peritoneum than KIR2DS5- and KIR2DS4del -negative ones (OR = 0.077, P  = 0.0061). Similarly, KIR2DS4del -positive endometriotic persons had 11 times lower chance for peritoneal disease (OR = 0.094, P  
ISSN:0093-7711
1432-1211
DOI:10.1007/s00251-015-0828-3