Calcium signalling in developing cardiomyocytes: implications for model systems and disease

Adult cardiomyocytes exhibit complex Ca2+ homeostasis, enabling tight control of contraction and relaxation. This intricate regulatory system develops gradually, with progressive maturation of specialized structures and increasing capacity of Ca2+ sources and sinks. In this review, we outline curren...

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Bibliographic Details
Published in:The Journal of physiology 2015-03, Vol.593 (5), p.1047-1063
Main Authors: Louch, William E., Koivumäki, Jussi T., Tavi, Pasi
Format: Article
Language:English
Subjects:
Animals
Calcium
Calcium Signaling
Cardiomyocytes
Cell Differentiation
Heart - embryology
Heart - physiology
Heart - physiopathology
Homeostasis
Humans
Myocytes, Cardiac - cytology
Myocytes, Cardiac - metabolism
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Summary:Adult cardiomyocytes exhibit complex Ca2+ homeostasis, enabling tight control of contraction and relaxation. This intricate regulatory system develops gradually, with progressive maturation of specialized structures and increasing capacity of Ca2+ sources and sinks. In this review, we outline current understanding of these developmental processes, and draw parallels to pathophysiological conditions where cardiomyocytes exhibit a striking regression to an immature state of Ca2+ homeostasis. We further highlight the importance of understanding developmental physiology when employing immature cardiomyocyte models such as cultured neonatal cells and stem cells.
ISSN:0022-3751
1469-7793
DOI:10.1113/jphysiol.2014.274712