Horizons of psychiatric genetics and epigenetics: where are we and where are we heading?

Today multinational studies using genome-wide association scan (GWAS) for >1000,000 polymorphisms on >100,000 cases with major psychiatric diseases versus controls, combined with next-generation sequencing have found ~100 genetic polymorphisms associated with schizophrenia (SCZ), bipolar disor...

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Bibliographic Details
Published in:Iranian journal of psychiatry and behavioral sciences 2014, Vol.8 (3), p.1-10
Main Author: Mostafavi Abdolmaleky, Hamid
Format: Article
Language:English
Online Access:Get full text
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Summary:Today multinational studies using genome-wide association scan (GWAS) for >1000,000 polymorphisms on >100,000 cases with major psychiatric diseases versus controls, combined with next-generation sequencing have found ~100 genetic polymorphisms associated with schizophrenia (SCZ), bipolar disorder (BD), autism, attention deficit and hyperactivity disorder (ADHD), etc. However, the effect size of each genetic mutation has been generally low (
ISSN:1735-8639
1735-9287