Discriminative-stimulus effects of second generation synthetic cathinones in methamphetamine-trained rats

Highlights • We tested the discriminative stimulus effects of second-generation synthetic cathinones in methamphetamine-trained rats. • Alpha-PVP and 4-MePPP both substituted for methamphetamine. • 4-MEC did not substitute for methamphetamine.

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Bibliographic Details
Published in:Drug and alcohol dependence 2015-04, Vol.149, p.280-284
Main Authors: Naylor, Jennifer E, Freeman, Kevin B, Blough, Bruce E, Woolverton, William L, Huskinson, Sally L
Format: Article
Language:English
Subjects:
Amphetamines - pharmacology
Animals
Central Nervous System Stimulants - pharmacology
Conditioning, Operant - drug effects
Designer Drugs - pharmacology
Discrimination Learning - drug effects
Dose-Response Relationship, Drug
Drug discrimination
Male
Methamphetamine
Methamphetamine - pharmacology
Propiophenones - pharmacology
Psychiatry
Pyrroles - pharmacology
Pyrrolidines - pharmacology
Rats
Self Administration
Synthetic cathinones
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Summary:Highlights • We tested the discriminative stimulus effects of second-generation synthetic cathinones in methamphetamine-trained rats. • Alpha-PVP and 4-MePPP both substituted for methamphetamine. • 4-MEC did not substitute for methamphetamine.
ISSN:0376-8716
1879-0046
DOI:10.1016/j.drugalcdep.2015.02.002