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Histopathological and immune alterations in autopsied kidneys
To collect data on all detectable histologic and immune alterations from the kidneys of 55 autopsy cases. This prospective study was carried out at the Department of Pathology, Medical Faculty, Trakya University, Edirne, Turkey. Fifty-five cases were subjected to the study among 248 autopsies that w...
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| Published in: | Saudi medical journal 2014-11, Vol.35 (11), p.1331-1338 |
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| container_end_page | 1338 |
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| container_title | Saudi medical journal |
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| creator | Usta, Ufuk Tastekin, Ebru Isler, Erhan Kutlu, Ali K Oz Puyan, Fulya |
| description | To collect data on all detectable histologic and immune alterations from the kidneys of 55 autopsy cases.
This prospective study was carried out at the Department of Pathology, Medical Faculty, Trakya University, Edirne, Turkey. Fifty-five cases were subjected to the study among 248 autopsies that were performed in 2011 and 2012. All kidney samples were evaluated under a light microscope and fresh tissue samples were used for immunofluorescence microscopy. Immunohistochemically kappa (κ) and lambda (λ) antibodies were applied to the tissue sections. The glomerular, tubulo-interstitial, and vascular alterations, as well as immune depositions were noted.
The microscopic morphology was close to normal histology in only 23 cases, and 23 cases had glomerular alterations. Nineteen cases had at least one immune deposition. There was immunoglobulin A deposition in 13 cases, and 9 cases showed positivity for both κ and λ immunohistochemically, and there was no clonal positivity.
The most striking outcome of our study is the high rate of immune depositions. There was also a significant number of glomerular and non-glomerular renal alterations. |
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This prospective study was carried out at the Department of Pathology, Medical Faculty, Trakya University, Edirne, Turkey. Fifty-five cases were subjected to the study among 248 autopsies that were performed in 2011 and 2012. All kidney samples were evaluated under a light microscope and fresh tissue samples were used for immunofluorescence microscopy. Immunohistochemically kappa (κ) and lambda (λ) antibodies were applied to the tissue sections. The glomerular, tubulo-interstitial, and vascular alterations, as well as immune depositions were noted.
The microscopic morphology was close to normal histology in only 23 cases, and 23 cases had glomerular alterations. Nineteen cases had at least one immune deposition. There was immunoglobulin A deposition in 13 cases, and 9 cases showed positivity for both κ and λ immunohistochemically, and there was no clonal positivity.
The most striking outcome of our study is the high rate of immune depositions. There was also a significant number of glomerular and non-glomerular renal alterations. </description><identifier>ISSN: 0379-5284</identifier><identifier>EISSN: 1658-3175</identifier><identifier>PMID: 25399209</identifier><language>eng</language><publisher>Saudi Arabia: Saudi Medical Journal</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Autopsy ; Female ; Forensic Pathology ; Humans ; Immunoglobulin A - immunology ; Immunoglobulin A - metabolism ; Immunoglobulin kappa-Chains - immunology ; Immunoglobulin kappa-Chains - metabolism ; Immunoglobulin lambda-Chains - immunology ; Immunoglobulin lambda-Chains - metabolism ; Immunohistochemistry ; Kidney - immunology ; Kidney - metabolism ; Kidney - pathology ; Kidney Diseases - epidemiology ; Kidney Diseases - immunology ; Kidney Diseases - pathology ; Kidney Glomerulus - immunology ; Kidney Glomerulus - metabolism ; Kidney Glomerulus - pathology ; Male ; Microscopy, Fluorescence ; Middle Aged ; Prospective Studies ; Turkey ; Young Adult</subject><ispartof>Saudi medical journal, 2014-11, Vol.35 (11), p.1331-1338</ispartof><rights>Copyright: © Saudi Medical Journal 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362145/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362145/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25399209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Usta, Ufuk</creatorcontrib><creatorcontrib>Tastekin, Ebru</creatorcontrib><creatorcontrib>Isler, Erhan</creatorcontrib><creatorcontrib>Kutlu, Ali K</creatorcontrib><creatorcontrib>Oz Puyan, Fulya</creatorcontrib><title>Histopathological and immune alterations in autopsied kidneys</title><title>Saudi medical journal</title><addtitle>Saudi Med J</addtitle><description>To collect data on all detectable histologic and immune alterations from the kidneys of 55 autopsy cases.
This prospective study was carried out at the Department of Pathology, Medical Faculty, Trakya University, Edirne, Turkey. Fifty-five cases were subjected to the study among 248 autopsies that were performed in 2011 and 2012. All kidney samples were evaluated under a light microscope and fresh tissue samples were used for immunofluorescence microscopy. Immunohistochemically kappa (κ) and lambda (λ) antibodies were applied to the tissue sections. The glomerular, tubulo-interstitial, and vascular alterations, as well as immune depositions were noted.
The microscopic morphology was close to normal histology in only 23 cases, and 23 cases had glomerular alterations. Nineteen cases had at least one immune deposition. There was immunoglobulin A deposition in 13 cases, and 9 cases showed positivity for both κ and λ immunohistochemically, and there was no clonal positivity.
The most striking outcome of our study is the high rate of immune depositions. There was also a significant number of glomerular and non-glomerular renal alterations. </description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autopsy</subject><subject>Female</subject><subject>Forensic Pathology</subject><subject>Humans</subject><subject>Immunoglobulin A - immunology</subject><subject>Immunoglobulin A - metabolism</subject><subject>Immunoglobulin kappa-Chains - immunology</subject><subject>Immunoglobulin kappa-Chains - metabolism</subject><subject>Immunoglobulin lambda-Chains - immunology</subject><subject>Immunoglobulin lambda-Chains - metabolism</subject><subject>Immunohistochemistry</subject><subject>Kidney - immunology</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Kidney Diseases - epidemiology</subject><subject>Kidney Diseases - immunology</subject><subject>Kidney Diseases - pathology</subject><subject>Kidney Glomerulus - immunology</subject><subject>Kidney Glomerulus - metabolism</subject><subject>Kidney Glomerulus - pathology</subject><subject>Male</subject><subject>Microscopy, Fluorescence</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Turkey</subject><subject>Young Adult</subject><issn>0379-5284</issn><issn>1658-3175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNpVkE1LAzEARIMotlb_guzRy0K-szkoSNFWKHjRc8gm2TaaTdZNVui_t2AVPc1hhvdgTsAccdbUBAl2CuaQCFkz3NAZuMj5DULCOeTnYIYZkRJDOQe3a59LGnTZpZC23uhQ6Wgr3_dTdJUOxY26-BRz5WOlp8M0e2erd2-j2-dLcNbpkN3VMRfg9fHhZbmuN8-rp-X9ph4w56UWGLaN1QJLi7GQxLCmRajjjkhkWCc7JKiwiGEpmBENIm3bGMQkctAwKjuyAHff3GFqe2eNi2XUQQ2j7_W4V0l79b-Jfqe26VNRwjGi7AC4OQLG9DG5XFTvs3Eh6OjSlBXihFIpiECH6fVf16_k5zPyBWncagc</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Usta, Ufuk</creator><creator>Tastekin, Ebru</creator><creator>Isler, Erhan</creator><creator>Kutlu, Ali K</creator><creator>Oz Puyan, Fulya</creator><general>Saudi Medical Journal</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141101</creationdate><title>Histopathological and immune alterations in autopsied kidneys</title><author>Usta, Ufuk ; Tastekin, Ebru ; Isler, Erhan ; Kutlu, Ali K ; Oz Puyan, Fulya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-720b8da729d22793c58b11f6e391c5f9f1747d152975c7813bb8c1591e0c549f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autopsy</topic><topic>Female</topic><topic>Forensic Pathology</topic><topic>Humans</topic><topic>Immunoglobulin A - immunology</topic><topic>Immunoglobulin A - metabolism</topic><topic>Immunoglobulin kappa-Chains - immunology</topic><topic>Immunoglobulin kappa-Chains - metabolism</topic><topic>Immunoglobulin lambda-Chains - immunology</topic><topic>Immunoglobulin lambda-Chains - metabolism</topic><topic>Immunohistochemistry</topic><topic>Kidney - immunology</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Kidney Diseases - epidemiology</topic><topic>Kidney Diseases - immunology</topic><topic>Kidney Diseases - pathology</topic><topic>Kidney Glomerulus - immunology</topic><topic>Kidney Glomerulus - metabolism</topic><topic>Kidney Glomerulus - pathology</topic><topic>Male</topic><topic>Microscopy, Fluorescence</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Turkey</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Usta, Ufuk</creatorcontrib><creatorcontrib>Tastekin, Ebru</creatorcontrib><creatorcontrib>Isler, Erhan</creatorcontrib><creatorcontrib>Kutlu, Ali K</creatorcontrib><creatorcontrib>Oz Puyan, Fulya</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Saudi medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Usta, Ufuk</au><au>Tastekin, Ebru</au><au>Isler, Erhan</au><au>Kutlu, Ali K</au><au>Oz Puyan, Fulya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathological and immune alterations in autopsied kidneys</atitle><jtitle>Saudi medical journal</jtitle><addtitle>Saudi Med J</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>35</volume><issue>11</issue><spage>1331</spage><epage>1338</epage><pages>1331-1338</pages><issn>0379-5284</issn><eissn>1658-3175</eissn><abstract>To collect data on all detectable histologic and immune alterations from the kidneys of 55 autopsy cases.
This prospective study was carried out at the Department of Pathology, Medical Faculty, Trakya University, Edirne, Turkey. Fifty-five cases were subjected to the study among 248 autopsies that were performed in 2011 and 2012. All kidney samples were evaluated under a light microscope and fresh tissue samples were used for immunofluorescence microscopy. Immunohistochemically kappa (κ) and lambda (λ) antibodies were applied to the tissue sections. The glomerular, tubulo-interstitial, and vascular alterations, as well as immune depositions were noted.
The microscopic morphology was close to normal histology in only 23 cases, and 23 cases had glomerular alterations. Nineteen cases had at least one immune deposition. There was immunoglobulin A deposition in 13 cases, and 9 cases showed positivity for both κ and λ immunohistochemically, and there was no clonal positivity.
The most striking outcome of our study is the high rate of immune depositions. There was also a significant number of glomerular and non-glomerular renal alterations. </abstract><cop>Saudi Arabia</cop><pub>Saudi Medical Journal</pub><pmid>25399209</pmid><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Autopsy Female Forensic Pathology Humans Immunoglobulin A - immunology Immunoglobulin A - metabolism Immunoglobulin kappa-Chains - immunology Immunoglobulin kappa-Chains - metabolism Immunoglobulin lambda-Chains - immunology Immunoglobulin lambda-Chains - metabolism Immunohistochemistry Kidney - immunology Kidney - metabolism Kidney - pathology Kidney Diseases - epidemiology Kidney Diseases - immunology Kidney Diseases - pathology Kidney Glomerulus - immunology Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Male Microscopy, Fluorescence Middle Aged Prospective Studies Turkey Young Adult |
| title | Histopathological and immune alterations in autopsied kidneys |
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