Assessment of relatedness between neurocan gene as bipolar disorder susceptibility locus and schizophrenia

Large scale genetic association meta-analyses showed that neurocan (NCAN) gene polymorphism rs1064395 is susceptibility locus for bipolar disorder. These studies also included patients with bipolar disorder originated from Bosnia and Herzegovina. Followed by theory of shared genetic elements between...

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Bibliographic Details
Published in:Biomolecules & biomedicine 2012-11, Vol.12 (4), p.245-248
Main Authors: Oruc, Lilijana, Kapur-Pojskic, Lejla, Ramic, Jasmin, Pojskic, Naris, Bajrovic, Kasim
Format: Article
Language:English
Subjects:
Analysis
Base Sequence
Bipolar disorder
Bipolar Disorder - genetics
Chondroitin Sulfate Proteoglycans - genetics
Disease susceptibility
Genetic aspects
genetic association
Genetic Predisposition to Disease
Health aspects
Humans
Lectins
Lectins, C-Type - genetics
Molecular Sequence Data
NCAN (neurocan)
Nerve Tissue Proteins - genetics
Quantitative trait loci
Risk factors
Schizophrenia
Schizophrenia - genetics
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Summary:Large scale genetic association meta-analyses showed that neurocan (NCAN) gene polymorphism rs1064395 is susceptibility locus for bipolar disorder. These studies also included patients with bipolar disorder originated from Bosnia and Herzegovina. Followed by theory of shared genetic elements between bipolar disorder and schizophrenia susceptibility, other studies explored several genetic factors with schizophrenia vulnerability as well. In this work, authors investigated the association between previously confirmed bipolar disorder genetic risk factor- neurocan with schizophrenia in a population sample of Bosnia and Herzegovina. Ethical aspects of this research were assessed by Ethics Committee of Clinical Center University of Sarajevo. Blood samples for DNA extraction were taken from the total of 86 patients and healthy individuals who previously signed informed consent. Genotyping for rs 1064395 was done using direct sequencing method. A case-control analysis of common genetic polymorphism within neurocan gene and schizophrenia status in a consecutively sampled patient cohort have been done using Fisher-exact test with odds-ratio calculation. No statistically significant allele and genotype association with disease status was found (p>0.05). Our finding supports the fact that large-scale genetic association studies approach need to be employed when detecting the variants with small additive effect in phenotypes with complex ethiology.
ISSN:1512-8601
2831-0896
1840-4812
2831-090X
DOI:10.17305/bjbms.2012.2446