Etoposide Incorporated into Camel Milk Phospholipids Liposomes Shows Increased Activity against Fibrosarcoma in a Mouse Model

Phospholipids were isolated from camel milk and identified by using high performance liquid chromatography and gas chromatography-mass spectrometry (GC/MS). Anticancer drug etoposide (ETP) was entrapped in liposomes, prepared from camel milk phospholipids, to determine its activity against fibrosarc...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-11
Main Authors: Alsharidah, Mansour S., Alorainy, Mohammed S., Aljarbou, Ahmad N., Maswadeh, Hamzah M., Khan, Masood A.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - chemistry
Camelus
Cancer
Colleges & universities
Diffusion
Drug delivery systems
Drug Synergism
Etoposide
Etoposide - administration & dosage
Etoposide - chemistry
Female
Fibrosarcoma
Fibrosarcoma - drug therapy
Fibrosarcoma - pathology
Health aspects
Lipids
Liposomes - chemistry
Mice
Mice, Inbred BALB C
Milk
Milk - chemistry
Milk proteins
Phospholipids
Phospholipids - chemistry
Physiological aspects
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Phospholipids were isolated from camel milk and identified by using high performance liquid chromatography and gas chromatography-mass spectrometry (GC/MS). Anticancer drug etoposide (ETP) was entrapped in liposomes, prepared from camel milk phospholipids, to determine its activity against fibrosarcoma in a murine model. Fibrosarcoma was induced in mice by injecting benzopyrene (BAP) and tumor-bearing mice were treated with various formulations of etoposide, including etoposide entrapped camel milk phospholipids liposomes (ETP-Cam-liposomes) and etoposide-loaded DPPC-liposomes (ETP-DPPC-liposomes). The tumor-bearing mice treated with ETP-Cam-liposomes showed slow progression of tumors and increased survival compared to free ETP or ETP-DPPC-liposomes. These results suggest that ETP-Cam-liposomes may prove to be a better drug delivery system for anticancer drugs.
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/743051