Hepatoprotective Effect of Silymarin (Silybum marianum) on Hepatotoxicity Induced by Acetaminophen in Spontaneously Hypertensive Rats

This study was aimed to investigate the effect of Silymarin (SLM) on the hypertension state and the liver function changes induced by acetaminophen (APAP) in spontaneously hypertensive rat (SHR). Animals normotensive (N) or hypertensive (SHR) were treated or not with APAP (3 g/kg, oral) or previousl...

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Published in:Evidence-based complementary and alternative medicine 2015-01, Vol.2015 (2015), p.1-8
Main Authors: Cuman, Roberto Kenji Nakamura, Bersani-Amado, Ciomar Aparecida, Grespan, Renata, Spironello, Ricardo Alexandre, Silva-Comar, Francielli Maria de Souza, Aguiar, Rafael Pazinatto, da Rocha, Bruno Ambrósio, Cardia, Gabriel Fernando Esteves, Freitag, Abel Felipe, Caparroz-Assef, Silvana Martins
Format: Article
Language:English
Subjects:
Acetaminophen
Animals
Antioxidants
Aspartate
Dextrose
Drugs
Enzymes
Free radicals
Glucose
Heart attacks
Hypertension
Liver
Liver diseases
Phosphatases
Rodents
Studies
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Summary:This study was aimed to investigate the effect of Silymarin (SLM) on the hypertension state and the liver function changes induced by acetaminophen (APAP) in spontaneously hypertensive rat (SHR). Animals normotensive (N) or hypertensive (SHR) were treated or not with APAP (3 g/kg, oral) or previously treated with SLM. Twelve hours after APAP administration, plasmatic levels of liver function markers: alanine aminotransferase (ALT), aspartate aminotransferase (AST), glucose (GLU), gamma glutamyl transferase (γ-GT), and alkaline phosphatase (ALP) of all groups, were determined. Liver injury was assessed using histological studies. Samples of their livers were then used to determine the myeloperoxidase (MPO) activity and nitric oxide (NO) production and were also sectioned for histological analysis. No differences were observed for ALT, γ-GT, and GLU levels between SHR and normotensive rats groups. However, AST and ALP levels were increased in hypertensive animals. APAP treatment promoted an increase in ALT and AST in both SHR and N. However, only for SHR, γ-GT levels were increased. The inflammatory response evaluated by MPO activity and NO production showed that SHR was more susceptible to APAP effect, by increasing leucocyte infiltration. Silymarin treatment (Legalon) restored the hepatocyte functional and histopathological alterations induced by APAP in normotensive and hypertensive animals.
ISSN:1741-427X
1741-4288
DOI:10.1155/2015/538317