Argonautes team up to silence transposable elements in Arabidopsis

The de novo silencing of transposable elements in plants and animals is mediated in part by RNA‐directed chromatin modification. In flowering plants, AGO4 has been seen as the key argonaute protein in the RNA‐directed DNA methylation pathway that links the plant‐specific RNA polymerase V with the de...

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Bibliographic Details
Published in:The EMBO journal 2015-03, Vol.34 (5), p.579-580
Main Authors: Underwood, Charles J, Martienssen, Robert A
Format: Article
Language:English
Subjects:
Arabidopsis - genetics
Arabidopsis Proteins - metabolism
Argonaute Proteins - metabolism
Botany
Chromatin
DNA Methylation - genetics
DNA-Directed RNA Polymerases - metabolism
EMBO09
EMBO30
EMBO36
Flowering plants
Gene Silencing - physiology
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Proteins
RNA polymerase
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Summary:The de novo silencing of transposable elements in plants and animals is mediated in part by RNA‐directed chromatin modification. In flowering plants, AGO4 has been seen as the key argonaute protein in the RNA‐directed DNA methylation pathway that links the plant‐specific RNA polymerase V with the de novo DNA methyltransferase DRM2 (Zhong et al , 2014). Two recent papers in The EMBO Journal strongly implicate a role for the AGO6 protein in the process of de novo silencing. Graphical Abstract Two studies reveal that AGO6 cooperates with other argonaute proteins to silence transposable elements in plants.
ISSN:0261-4189
1460-2075
DOI:10.15252/embj.201590971