Exploratory Clinical Trial to Evaluate the Efficacy of a Topical Traditional Chinese Herbal Medicine in Psoriasis Vulgaris

Objective. To evaluate the efficacy and safety of herbal ointment, Shi Du Ruan Gao, in patients with plaque-type psoriasis. Design. Single-center, randomized, investigator-blinded, parallel group, placebo-controlled study. Participants. One hundred outpatients with mild to moderate chronic plaque-ty...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2015-01, Vol.2015 (2015), p.1-6
Main Authors: Feng, Lilian, Briantais, Philippe, Chantalat, Laurent, Pernin, Colette, Andres, Philippe, Liu, Wali, Yan, Yuhe, Lin, Albert
Format: Article
Language:English
Subjects:
Chinese medicine
Clinical trials
Drug therapy
Hospitals
Medicine, Botanic
Medicine, Chinese
Medicine, Herbal
Phosphorylation
Psoriasis
R&D
Research & development
Skin
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Summary:Objective. To evaluate the efficacy and safety of herbal ointment, Shi Du Ruan Gao, in patients with plaque-type psoriasis. Design. Single-center, randomized, investigator-blinded, parallel group, placebo-controlled study. Participants. One hundred outpatients with mild to moderate chronic plaque-type psoriasis were enrolled. Intervention. The patients applied either Shi Du Ruan Gao ointment or vehicle ointment topically to for 8 weeks. Main Outcome Measures. The outcomes were assessed using the following criteria: Total Severity Score (TSS, sum of erythema, scaling, and plaque elevation/induration, on a 0 to 4 scale), Investigator Global Assessment (IGA) evaluated on a 0 (Clear) to 4 (s to very severe) scale, and Global Subjects’ Assessment of treatment response on a 7-point scale from −1 (worse) to 5 (Cleared). Results. Significant reductions in the Total Severity Score (P
ISSN:1741-427X
1741-4288
DOI:10.1155/2015/719641