Mixed large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder: a case report and brief review of the literature

Large-cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare. We present a 63-year-old Chinese female who was admitted with right upper quadrant pain and a quasi-circular tumor measuring 2.0 cm on the body of the gallbladder, as indicated by computed tomography. LCNEC combined wi...

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Bibliographic Details
Published in:World journal of surgical oncology 2015-03, Vol.13 (1), p.114-114, Article 114
Main Authors: Liu, Wei, Wang, Lei, He, Xiao-dong, Feng, Cheng, Chang, Xiao-yan, Lu, Zhao-hui
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Carcinoma, Large Cell - pathology
Carcinoma, Large Cell - surgery
Carcinoma, Neuroendocrine - pathology
Carcinoma, Neuroendocrine - surgery
Care and treatment
Case Report
Case studies
Diagnosis
Female
Gallbladder Neoplasms - pathology
Gallbladder Neoplasms - surgery
Humans
Metastasis
Middle Aged
Neoplasms, Multiple Primary - pathology
Neoplasms, Multiple Primary - surgery
Prognosis
Tomography, X-Ray Computed
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Summary:Large-cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare. We present a 63-year-old Chinese female who was admitted with right upper quadrant pain and a quasi-circular tumor measuring 2.0 cm on the body of the gallbladder, as indicated by computed tomography. LCNEC combined with adenocarcinoma was immunohistochemically confirmed after open radical cholecystectomy. Postoperative recovery of this patient was uneventful, and no evidence of recurrence or metastasis was observed after 12 months of follow-up. LCNEC of the gallbladder is thought to be extremely rare and is usually found in combination with other histological carcinoma types, such as adenocarcinoma, as determined histologically. The prognosis is poor overall, but early detection with complete resection may result in a relatively good prognosis.
ISSN:1477-7819
1477-7819
DOI:10.1186/s12957-015-0533-6