Rapid cycling as a feature of bipolar disorder and comorbid migraine

Abstract Background Previous research has suggested the clinical profile of individuals with bipolar disorder (BD) differs according to the presence or absence of comorbid migraine. We aimed to determine the clinical characteristics that differentiate individuals with BD with and without comorbid mi...

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Bibliographic Details
Published in:Journal of affective disorders 2015-04, Vol.175, p.320-324
Main Authors: Gordon-Smith, K, Forty, L, Chan, C, Knott, S, Jones, I, Craddock, N, Jones, L.A
Format: Article
Language:English
Subjects:
Adolescent
Bipolar disorder
Bipolar Disorder - epidemiology
Brief Report
Comorbidity
Confounding Factors, Epidemiologic
Cross-Sectional Studies
Female
Humans
Middle Aged
Migraine
Migraine Disorders - diagnosis
Migraine Disorders - epidemiology
Odds Ratio
Panic Disorder - epidemiology
Psychiatry
Rapid cycling
Self Report
Surveys and Questionnaires
United Kingdom - epidemiology
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Summary:Abstract Background Previous research has suggested the clinical profile of individuals with bipolar disorder (BD) differs according to the presence or absence of comorbid migraine. We aimed to determine the clinical characteristics that differentiate individuals with BD with and without comorbid migraine in a large, representative, clinically well-characterised UK sample. Methods The lifetime clinical characteristics of 1488 individuals with BD (BPI n =1120, BPII n =368) with and without comorbid migraine were compared ( n =375 vs. n =1113 respectively). Results Individuals with BD and comorbid migraine had a distinctive set of lifetime clinical characteristics. A multivariate model showed that consistent with previous studies those with comorbid migraine were significantly more likely to be female (OR=2.099, p =0.005) and have comorbid panic attacks (OR=1.842, p =0.004). A novel finding was that even after controlling for other differences, the individuals with BD and comorbid migraine were more likely to have a rapid cycling illness course (OR=1.888, p =0.002). Limitations Presence of migraine was assessed using self report measures. Cross-sectional study design limits investigations of bidirectional associations between migraine and bipolar disorder. Conclusions Comorbid migraine in BD may represent a more homogenous subtype of BD with an unstable rapid cycling course. Identifying individuals with BD and comorbid migraine may be of use in a clinical setting and this subgroup could be the focus of future aetiological studies.
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2015.01.024