Fluorescence of experimental atheromatous plaques with hematoporphyrin derivative

Fluorescence of hematoporphyrin derivative (HPD) has been used clinically to localize malignant neoplasms because of its selective accumulation in these tissues. We tested the hypothesis that HPD may also be selectively concentrated within atheromatous plaques. 48 h after HPD injection in a variety...

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Bibliographic Details
Published in:The Journal of clinical investigation 1983-02, Vol.71 (2), p.395-399
Main Authors: Spears, J R, Serur, J, Shropshire, D, Paulin, S
Format: Article
Language:English
Subjects:
Animals
Aorta - analysis
Aorta - pathology
Arteriosclerosis - metabolism
Arteriosclerosis - pathology
Chickens
Dogs
Erythrocebus patas
Female
Guinea Pigs
Hematoporphyrins - administration & dosage
Hematoporphyrins - analysis
Male
Microscopy, Fluorescence
Rabbits
Rats
Rats, Inbred Strains
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Summary:Fluorescence of hematoporphyrin derivative (HPD) has been used clinically to localize malignant neoplasms because of its selective accumulation in these tissues. We tested the hypothesis that HPD may also be selectively concentrated within atheromatous plaques. 48 h after HPD injection in a variety of species, selective fluorescence of atheromatous plaques of the aorta was seen in each animal (rabbits and Patas monkey) exhibiting such lesions. No fluorescence could be demonstrated in aortic segments free of atheromatous involvement. Since the efficacy of photodynamic destruction of malignant tumors with HPD has been demonstrated in clinical studies, the observations of the present study may have therapeutic implications in atheromatosis.
ISSN:0021-9738
DOI:10.1172/JCI110782