Circulating Cytokines and Alarmins Associated with Placental Inflammation in High-Risk Pregnancies

Problem Inflammation during pregnancy has devastating consequences for the placenta and fetus. These events are incompletely understood, thereby hampering screening and treatment. Method of study The inflammatory profile of villous tissue was studied in pregnancies at high‐risk of placental dysfunct...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2014-10, Vol.72 (4), p.422-434
Main Authors: Girard, Sylvie, Heazell, Alexander E. P., Derricott, Hayley, Allan, Stuart M., Sibley, Colin P., Abrahams, Vikki M., Jones, Rebecca L.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - blood
Clinical Aspects of Reproductive Immunology
Cytokines - blood
Female
Fetuses
High-risk pregnancy
HMGB1 Protein - blood
Humans
Inflammation
Inflammation - blood
Interleukin 1 Receptor Antagonist Protein - blood
Interleukin-10 - blood
Interleukin-18 - blood
Interleukin-1alpha - blood
Interleukin-1beta - blood
Macrophages - immunology
Placenta - immunology
Placenta - physiopathology
placental dysfunction
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - physiopathology
Pregnancy, High-Risk - blood
Prenatal development
stillbirth
Young Adult
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Summary:Problem Inflammation during pregnancy has devastating consequences for the placenta and fetus. These events are incompletely understood, thereby hampering screening and treatment. Method of study The inflammatory profile of villous tissue was studied in pregnancies at high‐risk of placental dysfunction and compared to uncomplicated pregnancies. The systemic inflammatory profile was assessed in matched maternal serum samples in cases of reduced fetal movements (RFM). Results Placentas from RFM pregnancies had a unique inflammatory profile characterized by increased interleukin (IL)‐1 receptor antagonist and decreased IL‐10 expression, concomitant with increased numbers of placental macrophages. This aberrant cytokine profile was evident in maternal serum in RFM, as were increased levels of alarmins (uric acid, HMGB1, cell‐free fetal DNA). Conclusion This distinct inflammatory profile at the maternal‐fetal interface, mirrored in maternal serum, could represent biomarkers of placental inflammation and could offer novel therapeutic options to protect the placenta and fetus from an adverse maternal environment.
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.12274