Cannabinoid agonist rescues learning and memory after a traumatic brain injury

Traumatic brain injury can cause persistent challenges including problems with learning and memory. Previous studies suggest that the activation of the cannabinoid 1 receptor after a traumatic brain injury could be beneficial. We tested the hypothesis that posttraumatic brain injury administration o...

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Bibliographic Details
Published in:Annals of clinical and translational neurology 2015-03, Vol.2 (3), p.289-294
Main Authors: Arain, Marium, Khan, Maida, Craig, Laura, Nakanishi, Stan T.
Format: Article
Language:English
Subjects:
Addictive behaviors
Animal cognition
Behavior
Brain research
Brief Communications
Drug dosages
Memory
Metabolism
Rodents
Studies
Substance abuse treatment
Traumatic brain injury
Young adults
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Summary:Traumatic brain injury can cause persistent challenges including problems with learning and memory. Previous studies suggest that the activation of the cannabinoid 1 receptor after a traumatic brain injury could be beneficial. We tested the hypothesis that posttraumatic brain injury administration of a cannabinoid 1 receptor agonist can rescue deficits in learning and memory. Young adult male rats were subjected to a moderately severe controlled cortical impact brain injury, with a subset given postinjury i.p. injections of a cannabinoid receptor agonist. Utilizing novel object recognition and the morris water task, we found that the brain‐injured animals treated with the agonist showed a marked recovery.
ISSN:2328-9503
2328-9503
DOI:10.1002/acn3.163