Histopathology and clinical course of MOG‐antibody‐associated encephalomyelitis

We present histological, MRI, and clinical features of an adult patient with relapsing encephalomyelitis and antibodies against myelin oligodendrocyte glycoprotein (MOG). Furthermore, we report molecular details of the recognized epitope that is specific for human MOG. A brain biopsy revealed multip...

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Published in:Annals of clinical and translational neurology 2015-03, Vol.2 (3), p.295-301
Main Authors: Spadaro, Melania, Gerdes, Lisa Ann, Mayer, Marie C., Ertl‐Wagner, Birgit, Laurent, Sarah, Krumbholz, Markus, Breithaupt, Constanze, Högen, Tobias, Straube, Andreas, Giese, Armin, Hohlfeld, Reinhard, Lassmann, Hans, Meinl, Edgar, Kümpfel, Tania
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Language:English
Subjects:
Amino acids
Brief Communications
Encephalitis
Glycoproteins
Histopathology
Immunoglobulins
Monoclonal antibodies
NMR
Nuclear magnetic resonance
Patients
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cited_by cdi_FETCH-LOGICAL-c5044-7f17b80ca02965d6853fa961423b2f75b9593f7cc0972626323f41793abb06b73
cites cdi_FETCH-LOGICAL-c5044-7f17b80ca02965d6853fa961423b2f75b9593f7cc0972626323f41793abb06b73
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container_issue 3
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container_title Annals of clinical and translational neurology
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creator Spadaro, Melania
Gerdes, Lisa Ann
Mayer, Marie C.
Ertl‐Wagner, Birgit
Laurent, Sarah
Krumbholz, Markus
Breithaupt, Constanze
Högen, Tobias
Straube, Andreas
Giese, Armin
Hohlfeld, Reinhard
Lassmann, Hans
Meinl, Edgar
Kümpfel, Tania
description We present histological, MRI, and clinical features of an adult patient with relapsing encephalomyelitis and antibodies against myelin oligodendrocyte glycoprotein (MOG). Furthermore, we report molecular details of the recognized epitope that is specific for human MOG. A brain biopsy revealed multiple sclerosis (MS)‐type II pathology. Some features overlapped with both MS and neuromyelitis optica spectrum disorders (NMOSD), whereas others were distinct from both MS and NMOSD. Immunoadsorption and rituximab induced clinical stabilization. This case contributes a new, so far missing link in the emerging spectrum of MOG‐antibody‐associated encephalomyelitis.
doi_str_mv 10.1002/acn3.164
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subjects Amino acids
Brief Communications
Encephalitis
Glycoproteins
Histopathology
Immunoglobulins
Monoclonal antibodies
NMR
Nuclear magnetic resonance
Patients
title Histopathology and clinical course of MOG‐antibody‐associated encephalomyelitis
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