Determination of Abraham model solute descriptors for the monomeric and dimeric forms of trans-cinnamic acid using measured solubilities from the Open Notebook Science Challenge

• Published in: BMC chemistry 2015-03, Vol.9 (1), p.11-11, Article 11
• Main Authors: Bradley, Jean-Claude, Abraham, Michael H, Acree, William E, Lang, Andrew SID, Beck, Samantha N, Bulger, David A, Clark, Elizabeth A, Condron, Lacey N, Costa, Stephanie T, Curtin, Evan M, Kurtu, Sozit B, Mangir, Mark I, McBride, Matthew J
• Format: Article
• Language: English
• Subjects: Carboxylic acids; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Dimers; Dissolution; Mathematical models; Partitions; Permissible error; Research Article; Solubility; Solvents
• ISSN: 1752-153X; 1752-153X; 2661-801X
• DOI: 10.1186/s13065-015-0080-9

Background Calculating Abraham descriptors from solubility values requires that the solute have the same form when dissolved in all solvents. However, carboxylic acids can form dimers when dissolved in non-polar solvents. For such compounds Abraham descriptors can be calculated for both the monomeric and dimeric forms by treating the polar and non-polar systems separately. We illustrate the method of how this can be done by calculating the Abraham descriptors for both the monomeric and dimeric forms of trans-cinnamic acid, the first time that descriptors for a carboxylic acid dimer have been obtained. Results Abraham descriptors were calculated for the monomeric form of trans-cinnamic acid using experimental solubility measurements in polar solvents from the Open Notebook Science Challenge together with a number of water-solvent partition coefficients from the literature. Similarly, experimental solubility measurements in non-polar solvents were used to determine Abraham descriptors for the trans-cinnamic acid dimer. Conclusion Abraham descriptors were calculated for both the monomeric and dimeric forms of trans-cinnamic acid. This allows for the prediction of further solubilities of trans-cinnamic acid in both polar and non-polar solvents with an error of about 0.10 log units. Graphical abstract Molar concentration of trans-cinnamic acid in various polar and non-polar solvents.