Shengmai Injection Improved Doxorubicin-Induced Cardiomyopathy by Alleviating Myocardial Endoplasmic Reticulum Stress and Caspase-12 Dependent Apoptosis

Background. Apoptosis plays vital roles in the progression of doxorubicin-induced cardiomyopathy (DOX-CM). Endoplasmic reticulum stress (ER stress) could induce specific apoptosis by caspase-12 dependent pathway. Shengmai Injection (SMI), a famous Traditional Chinese Medicine, could alleviate the he...

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Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-8
Main Authors: Huang, Xiao-Hong, Xie, Yu-Quan, Xiang, Yin, Tang, Yong, Chen, Yu, Zhang, Ya-Chen
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - adverse effects
Antibiotics, Antineoplastic - pharmacology
Apoptosis
Apoptosis - drug effects
Cardiomyocytes
Cardiomyopathies - chemically induced
Cardiomyopathies - drug therapy
Cardiomyopathies - metabolism
Cardiomyopathies - pathology
Cardiomyopathy
Caspase 12 - metabolism
Chinese medicine
Doxorubicin - adverse effects
Doxorubicin - pharmacology
Drugs, Chinese Herbal - pharmacology
Endoplasmic reticulum
Endoplasmic Reticulum Stress - drug effects
Free radicals
Health aspects
Heart attacks
Heart diseases
Heart failure
Hospitals
Laboratory animals
Male
Medicine, Chinese
Myocardium - metabolism
Myocardium - pathology
Observations
Oxidative stress
Pathogenesis
Prevention
Rats
Rats, Sprague-Dawley
Rodents
Studies
Ultrasonic imaging
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Summary:Background. Apoptosis plays vital roles in the progression of doxorubicin-induced cardiomyopathy (DOX-CM). Endoplasmic reticulum stress (ER stress) could induce specific apoptosis by caspase-12 dependent pathway. Shengmai Injection (SMI), a famous Traditional Chinese Medicine, could alleviate the heart damage via inhibiting myocardial apoptosis. However, it is unknown whether SMI can alleviate ER stress and its specific apoptosis in the setting of DOX-CM. Objective. To explore the effects of SMI on heart function, myocardial ER stress, and apoptosis of DOX-CM rats. Methods. Rats with DOX-CM were treated by SMI. Heart function was assessed by echocardiography and brain natriuretic peptide. Myocardial apoptosis was detected by TUNEL assay. ER stress was assessed by detecting the expressions of GRP78 and caspase-12. Results. At the end of eight-week, compared to control, significant heart dysfunction happened in DOX group. The ratio of apoptotic cardiomyocytes and the expressions of GRP78 and caspase-12 increased significantly (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/952671