Bone turnover biomarkers in obese postmenopausal Saudi women with type-II diabetes mellitus

There is a high prevalence of diabetes mellitus type-2 (T2DM) and osteoporosis are problems worldwide. In this study, we evaluated the correlation between T2DM and bone turnover in diabetic obese postmenopausal Saudi women. The present study included total of 65 T2-DM obese postmenopausal Saudi wome...

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Bibliographic Details
Published in:African health sciences 2015-01, Vol.15 (1), p.90-96
Main Authors: Alselami, Nada M, Noureldeen, Amani F H, Al-Ghamdi, Maryam A, Khan, Jalaluddin A, Moselhy, Said S
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - blood
Biomarkers - blood
Blood Glucose - metabolism
Bones
Calcium - blood
Case-Control Studies
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Diagnostic tests
Female
Health and Medicine
Humans
Middle Aged
Obesity
Obesity - blood
Older People
Osteocalcin - blood
Osteoporosis
Osteoporosis - blood
Osteoporosis - epidemiology
Parathyroid Hormone - blood
Postmenopause - blood
Procollagen - blood
Saudi Arabia - epidemiology
Women
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Summary:There is a high prevalence of diabetes mellitus type-2 (T2DM) and osteoporosis are problems worldwide. In this study, we evaluated the correlation between T2DM and bone turnover in diabetic obese postmenopausal Saudi women. The present study included total of 65 T2-DM obese postmenopausal Saudi women, (36 uncontrolled, 29 controlled). The following serum biochemical parameters were evaluated [fasting blood glucose (FBG), total calcium (Ca), phosphorus (Pi), parathyroid hormone (PTH), 1,25-(OH)2 Vitamin D3, osteocalcin (OC), procollagen (PICP) and cathepsin k (Cath K)]. Serum OC levels were significantly decreased in diabetic obese postmenopausal group compared to their respective healthy group (P < 0.004). PICP and Cath K were significantly elevated in diabetic postmenopausal group compared to the healthy group (P < 0.024 & 0.001). A significant elevation in 1,25(OH)2 Vitamin D3, Ca and Pi levels in diabetic obese postmenopausal patients group compared to the healthy group. However, a non-significant changes was observed in serum PTH level between different groups. In this study, the changes in the biochemical parameters and bone turnover markers in obese women are strong risk factors for diabetes development that may contribute to osteopenia and osteoporosis. The study showed the strong effect of T2DM on biochemical markers of bone turnover in obese postmenopausal Saudi women.
ISSN:1680-6905
1729-0503
DOI:10.4314/ahs.v15i1.12