Cardiac and renal function in a large cohort of amateur marathon runners

• Published in: Cardiovascular ultrasound 2015-03, Vol.13 (1), p.13-13, Article 13
• Main Authors: Hewing, Bernd, Schattke, Sebastian, Spethmann, Sebastian, Sanad, Wasiem, Schroeckh, Sabrina, Schimke, Ingolf, Halleck, Fabian, Peters, Harm, Brechtel, Lars, Lock, Jürgen, Baumann, Gert, Dreger, Henryk, Borges, Adrian C, Knebel, Fabian
• Format: Article
• Language: English
• Subjects: Aged; Athletic Performance - physiology; Cohort Studies; Echocardiography - methods; Heart Function Tests; Heart Ventricles - diagnostic imaging; Humans; Kidney - physiology; Kidney Function Tests; Male; Middle Aged; Physical Endurance - physiology; Physical Fitness - physiology; Running - physiology; Ventricular Function, Left - physiology; Young Adult
• ISSN: 1476-7120; 1476-7120
• DOI: 10.1186/s12947-015-0007-6

Participation of amateur runners in endurance races continues to increase. Previous studies of marathon runners have raised concerns about exercise-induced myocardial and renal dysfunction and damage. In our pooled analysis, we aimed to characterize changes of cardiac and renal function after marathon running in a large cohort of mostly elderly amateur marathon runners. A total of 167 participants of the Berlin-Marathon (female n = 89, male n = 78; age = 50.3 ± 11.4 years) were included and cardiac and renal function was analyzed prior to, immediately after and 2 weeks following the race by echocardiography and blood tests (including cardiac troponin T, NT-proBNP and cystatin C). Among the runners, 58% exhibited a significant increase in cardiac biomarkers after completion of the marathon. Overall, the changes in echocardiographic parameters for systolic or diastolic left and right ventricular function did not indicate relevant myocardial dysfunction. Notably, 30% of all participants showed >25% decrease in cystatin C-estimated glomerular filtration rate (GFR) from baseline directly after the marathon; in 8%, we observed a decline of more than 50%. All cardiac and renal parameters returned to baseline ranges within 2 weeks after the marathon. The increase in cardiac biomarkers after completing a marathon was not accompanied by relevant cardiac dysfunction as assessed by echocardiography. After the race, a high proportion of runners experienced a decrease in cystatin C-estimated GFR, which is suggestive of transient, exercise-related alteration of renal function. However, we did not observe persistent detrimental effects on renal function.