Mannose-binding lectin and ficolin-2 do not influence humoral immune response to hepatitis B vaccine

Highlights • Mannose-binding lectin deficiency enhances humoral vaccine response in animal studies. • Lectin complement proteins were evaluated in individuals after hepatitis B vaccination. • Ficolin-2 levels/mutations were not associated with hepatitis B vaccine non-response. • Mannose-binding lect...

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Bibliographic Details
Published in:Vaccine 2014-08, Vol.32 (37), p.4772-4777
Main Authors: Osthoff, Michael, Irungu, Elizabeth, Ngure, Kenneth, Mugo, Nelly, Thomas, Katherine K, Baeten, Jared M, Eisen, Damon P
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Antigens
Applied microbiology
Biological and medical sciences
Complement system
Confidence intervals
Female
Ficolin-2
Ficolins
Fundamental and applied biological sciences. Psychology
Genes
Genetics
Genotype
Hepatitis
Hepatitis B vaccination
Hepatitis B Vaccines - immunology
Hepatitis B virus
HIV
Human immunodeficiency virus
Human immunodeficiency virus 1
Human viral diseases
Humans
Immune response
Immunity, Humoral
Infections
Infectious diseases
Innate immunity
Kenya
Lectins
Lectins - genetics
Lectins - immunology
Liver cancer
Male
Mannose-binding lectin
Mannose-Binding Lectin - genetics
Mannose-Binding Lectin - immunology
Medical sciences
Microbiology
Mutation
Pattern recognition
Polymorphism, Genetic
Prospective Studies
Public health
Sexually transmitted diseases
STD
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral hepatitis
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Summary:Highlights • Mannose-binding lectin deficiency enhances humoral vaccine response in animal studies. • Lectin complement proteins were evaluated in individuals after hepatitis B vaccination. • Ficolin-2 levels/mutations were not associated with hepatitis B vaccine non-response. • Mannose-binding lectin codon 57 mutations were more frequent in vaccine non-responders. • Our results are in contrast to previous experimental studies.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.06.023