RANK-ligand (RANKL) expression in young breast cancer patients and during pregnancy

RANKL is important in mammary gland development during pregnancy and mediates the initiation and progression of progesterone-induced breast cancer. No clinical data are available on the effect of pregnancy on RANK/RANKL expression in young breast cancer patients. We used our previously published dat...

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Bibliographic Details
Published in:Breast cancer research : BCR 2015-02, Vol.17 (1), p.24-24, Article 24
Main Authors: Azim, Jr, Hatem A, Peccatori, Fedro A, Brohée, Sylvain, Branstetter, Daniel, Loi, Sherene, Viale, Giuseppe, Piccart, Martine, Dougall, William C, Pruneri, Giancarlo, Sotiriou, Christos
Format: Article
Language:English
Subjects:
Adult
Age Factors
Analysis
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Cancer patients
Care and treatment
Development and progression
Disease-Free Survival
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genes
Genetic aspects
Humans
Immunohistochemistry
Middle Aged
Neoplasm Grading
Neoplasm Metastasis
Physiological aspects
Pregnancy
Pregnant women
Progesterone
Prognosis
RANK Ligand - genetics
RANK Ligand - metabolism
Receptor Activator of Nuclear Factor-kappa B - genetics
Receptor Activator of Nuclear Factor-kappa B - metabolism
Signal Transduction
T cells
Tumor Burden
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Summary:RANKL is important in mammary gland development during pregnancy and mediates the initiation and progression of progesterone-induced breast cancer. No clinical data are available on the effect of pregnancy on RANK/RANKL expression in young breast cancer patients. We used our previously published dataset of 65 pregnant and 130 matched young breast cancer patients with full clinical, pathological, and survival information. 85% of patients had available transcriptomic data as well. RANK/RANKL expression by immunohistochemistry using H-score on the primary tumor and adjacent normal tissue was performed. We examined the difference in expression of RANK/RANKL between pregnant and non-pregnant patients and their association with clinicopathological features and prognosis. We also evaluated genes and pathways associated with RANK/RANKL expression on primary tumors. RANKL but not RANK expression was more prevalent in the pregnant group, both on the tumor and adjacent normal tissue, independent of other clinicopathological factors (both P
ISSN:1465-542X
1465-5411
1465-542X
DOI:10.1186/s13058-015-0538-7