Bladder Cancer Screening in Aluminum Smelter Workers

OBJECTIVE:To present results of a bladder cancer screening program conducted in 18 aluminum smelters in the United States from January 2000 to December 2010. METHODS:Data were collected on a cohort of workers with a history of working in coal tar pitch volatile exposed areas including urine analysis...

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Bibliographic Details
Published in:Journal of occupational and environmental medicine 2015-04, Vol.57 (4), p.421-427
Main Authors: Taiwo, Oyebode A., Slade, Martin D., Cantley, Linda F., Tessier-Sherman, Baylah, Galusha, Deron, Kirsche, Sharon R., Donoghue, A. Michael, Cullen, Mark R.
Format: Article
Language:English
Subjects:
Adult
Aged
Aluminum
Bladder cancer
Coal Tar
Early Detection of Cancer - methods
Female
Follow-Up Studies
Humans
Incidence
Male
Metallurgy
Middle Aged
Occupational Diseases - diagnosis
Occupational Diseases - epidemiology
Occupational Diseases - etiology
Occupational health
Original
Original Article
Sensitivity and Specificity
Surveillance
United States - epidemiology
Urinary Bladder Neoplasms - diagnosis
Urinary Bladder Neoplasms - epidemiology
Urinary Bladder Neoplasms - etiology
Workers
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Summary:OBJECTIVE:To present results of a bladder cancer screening program conducted in 18 aluminum smelters in the United States from January 2000 to December 2010. METHODS:Data were collected on a cohort of workers with a history of working in coal tar pitch volatile exposed areas including urine analysis for conventional cytology and ImmunoCyt/uCyt+ assay. RESULTS:ImmunoCyt/uCyt+ and cytology in combination showed a sensitivity of 62.30%, a specificity of 92.60%, a negative predictive value of 99.90%, and a positive predictive value of 2.96%. Fourteen cases of bladder cancer were detected, and the standardized incidence ratio of bladder cancer was 1.18 (95% confidence interval, 0.65 to 1.99). Individuals who tested positive on either test who were later determined to be cancer free had undergone expensive and invasive tests. CONCLUSIONS:Evidence to support continued surveillance of this cohort has not been demonstrated.
ISSN:1076-2752
1536-5948
DOI:10.1097/JOM.0000000000000377