Prognostic value of c-Met in colorectal cancer: a meta-analysis

• Published in: World journal of gastroenterology : WJG 2015-03, Vol.21 (12), p.3706-3710
• Main Authors: Liu, Yan, Yu, Xiao-Feng, Zou, Jian, Luo, Zi-Hua
• Format: Article
• Language: English
• Subjects: Biomarkers, Tumor - metabolism; Colorectal Neoplasms - enzymology; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Colorectal Neoplasms - therapy; Disease-Free Survival; Humans; Meta-Analysis; Odds Ratio; Proto-Oncogene Proteins c-met - metabolism; Risk Factors; Signal Transduction; Time Factors; Up-Regulation
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v21.i12.3706

To assess the prognostic value of c-Met status in colorectal cancer. We conducted a search in PubMed, Web of Science, and the Cochrane Library covering all published papers up to July 2014. Only studies assessing survival in colorectal cancer by c-Met status were included. This meta-analysis was performed by using STATA11.0. Ultimately, 11 studies were included in this analysis. Meta-analysis of the hazard ratios (HR) indicated that patients with high c-Met expression have a significantly poorer overall survival (OR) (HR = 1.33, 95%CI: 1.06-1.59) and progression-free survival (PFS) (HR = 1.47, 95%CI: 1.03-1.91). Subgroup analysis showed a significant association between high c-Met expression and poorer overall survival in the hazard ratio reported (HR = 1.41, 95%CI: 1.08-1.74). The present meta-analysis indicated that high c-Met expression was associated with poor prognosis in patients with colorectal cancer.