Helicobacter pylori infection, dementia and primary open-angle glaucoma: are they connected?

The study aims to elucidate the putative association between various forms of dementia, including Alzheimer's disease, primary open-angle glaucoma and Helicobacter pylori (H.pylori) infection in all possible combinations. We prospectively recruited for the study 156 patients, divided into a dem...

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Bibliographic Details
Published in:BMC ophthalmology 2015-03, Vol.15 (1), p.24-24, Article 24
Main Authors: Tsolaki, Fani, Kountouras, Jannis, Topouzis, Fotios, Tsolaki, Magda
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
Complications and side effects
Dementia - epidemiology
Dementia - etiology
Female
Follow-Up Studies
Glaucoma, Open-Angle - epidemiology
Glaucoma, Open-Angle - etiology
Greece - epidemiology
Health aspects
Helicobacter Infections - complications
Helicobacter Infections - epidemiology
Helicobacter Infections - microbiology
Helicobacter pylori - isolation & purification
Humans
Male
Medical research
Medicine, Experimental
Middle Aged
Morbidity - trends
Nervous system diseases
Prospective Studies
Risk Factors
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Summary:The study aims to elucidate the putative association between various forms of dementia, including Alzheimer's disease, primary open-angle glaucoma and Helicobacter pylori (H.pylori) infection in all possible combinations. We prospectively recruited for the study 156 patients, divided into a dementia group, a glaucoma group and two control groups. All patients were submitted to neuropsychological evaluation aiming to detect dementia, ophthalmological examination, aiming to detect glaucoma, and H.pylori diagnostic testing. The provided data were analyzed with the question of possible correlation between the aforementioned entities. Positive correlations were found between Hp infection and dementia, Hp infection and glaucoma, as well as between dementia and glaucoma. The study confirmed the hypothesis that neurodegenerative diseases such as dementia and glaucoma are linked to each other and to H.pylori infection.
ISSN:1471-2415
1471-2415
DOI:10.1186/s12886-015-0006-2