Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer

Highlights • Deregulation of ECM (i.e., desmoplastic ECM alignment) alters tumorigenesis. • Both biomechanical and biochemical factors promote desmoplastic ECM formation. • Cell–ECM ‘dynamic reciprocity’ is regulated by integrins and Rho–ROCK.

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2015-04, Vol.33 (4), p.230-236
Main Authors: Malik, Ruchi, Lelkes, Peter I, Cukierman, Edna
Format: Article
Language:English
Subjects:
Animals
Behavior
biomechanical and biochemical cues
Biomechanics
Biomedical Research
Breast cancer
Cell Line, Tumor
cell–ECM dynamic reciprocity
Collagen
desmoplasia
Enzymes
extracellular matrix
Extracellular Matrix - chemistry
Extracellular Matrix - metabolism
Genotype & phenotype
Homeostasis
Humans
integrins
Internal Medicine
Mice
Neoplasms - chemistry
Neoplasms - physiopathology
Pancreatic cancer
Physiology
Rho–ROCK
Tumor Microenvironment - physiology
Tumorigenesis
Wound healing
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Description
Summary:Highlights • Deregulation of ECM (i.e., desmoplastic ECM alignment) alters tumorigenesis. • Both biomechanical and biochemical factors promote desmoplastic ECM formation. • Cell–ECM ‘dynamic reciprocity’ is regulated by integrins and Rho–ROCK.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2015.01.004