Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer

Highlights • Deregulation of ECM (i.e., desmoplastic ECM alignment) alters tumorigenesis. • Both biomechanical and biochemical factors promote desmoplastic ECM formation. • Cell–ECM ‘dynamic reciprocity’ is regulated by integrins and Rho–ROCK.

Saved in:
Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2015-04, Vol.33 (4), p.230-236
Main Authors: Malik, Ruchi, Lelkes, Peter I, Cukierman, Edna
Format: Article
Language:English
Subjects:
Animals
Behavior
biomechanical and biochemical cues
Biomechanics
Biomedical Research
Breast cancer
Cell Line, Tumor
cell–ECM dynamic reciprocity
Collagen
desmoplasia
Enzymes
extracellular matrix
Extracellular Matrix - chemistry
Extracellular Matrix - metabolism
Genotype & phenotype
Homeostasis
Humans
integrins
Internal Medicine
Mice
Neoplasms - chemistry
Neoplasms - physiopathology
Pancreatic cancer
Physiology
Rho–ROCK
Tumor Microenvironment - physiology
Tumorigenesis
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c616t-949cc75c21eab6bd2ec5b26bd5730c558f036cac40f9159d6c5913bd98df3d233
cites cdi_FETCH-LOGICAL-c616t-949cc75c21eab6bd2ec5b26bd5730c558f036cac40f9159d6c5913bd98df3d233
container_end_page 236
container_issue 4
container_start_page 230
container_title Trends in biotechnology (Regular ed.)
container_volume 33
creator Malik, Ruchi
Lelkes, Peter I
Cukierman, Edna
description Highlights • Deregulation of ECM (i.e., desmoplastic ECM alignment) alters tumorigenesis. • Both biomechanical and biochemical factors promote desmoplastic ECM formation. • Cell–ECM ‘dynamic reciprocity’ is regulated by integrins and Rho–ROCK.
doi_str_mv 10.1016/j.tibtech.2015.01.004
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4380578</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0167779915000207</els_id><sourcerecordid>3660590791</sourcerecordid><originalsourceid>FETCH-LOGICAL-c616t-949cc75c21eab6bd2ec5b26bd5730c558f036cac40f9159d6c5913bd98df3d233</originalsourceid><addsrcrecordid>eNqFUk1v1DAQtRCILgs_ARSJC5eEcRzH8aUIKr6kSkh8nC1nMul6SeJiJ1X773HYpUAvnPz15vm9ecPYUw4FB16_3Beza2fCXVEClwXwAqC6xza8UToXoOv7bJNwKldK6xP2KMY9AAil-UN2UkoFjYZ6wz6_cX5MLHZyaIfMTl3WOo87Gn-dA42-o8FNF5nvszgHP6Zbup6DRRqGZbAhG-0c3HXmpgzthBQeswe9HSI9Oa5b9u3d269nH_LzT-8_nr0-z7Hm9ZzrSiMqiSUn29ZtVxLKtkwbqQSglE0PokaLFfSaS93VKDUXbaebrhddKcSWnR54L5d2pA5pSqoGcxncaMON8daZf18mtzMX_spUogGpmkTw4kgQ_I-F4mxGF1dbdiK_RMPrhpdS66pK0Od3oHu_hCnZSyhVVQ3nSfaWyQMKg48xUH8rhoNZUzN7c0zNrKkZ4Calluqe_e3ktup3TAnw6gCg1M8rR8FEdJSa3blAOJvOu_9-cXqHAVOqa8bf6YbiHzcmlgbMl3V01snhMk1NCUr8BBJ9wco</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1674481157</pqid></control><display><type>article</type><title>Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer</title><source>ScienceDirect Freedom Collection</source><creator>Malik, Ruchi ; Lelkes, Peter I ; Cukierman, Edna</creator><creatorcontrib>Malik, Ruchi ; Lelkes, Peter I ; Cukierman, Edna</creatorcontrib><description>Highlights • Deregulation of ECM (i.e., desmoplastic ECM alignment) alters tumorigenesis. • Both biomechanical and biochemical factors promote desmoplastic ECM formation. • Cell–ECM ‘dynamic reciprocity’ is regulated by integrins and Rho–ROCK.</description><identifier>ISSN: 0167-7799</identifier><identifier>EISSN: 1879-3096</identifier><identifier>DOI: 10.1016/j.tibtech.2015.01.004</identifier><identifier>PMID: 25708906</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Behavior ; biomechanical and biochemical cues ; Biomechanics ; Biomedical Research ; Breast cancer ; Cell Line, Tumor ; cell–ECM dynamic reciprocity ; Collagen ; desmoplasia ; Enzymes ; extracellular matrix ; Extracellular Matrix - chemistry ; Extracellular Matrix - metabolism ; Genotype &amp; phenotype ; Homeostasis ; Humans ; integrins ; Internal Medicine ; Mice ; Neoplasms - chemistry ; Neoplasms - physiopathology ; Pancreatic cancer ; Physiology ; Rho–ROCK ; Tumor Microenvironment - physiology ; Tumorigenesis ; Wound healing</subject><ispartof>Trends in biotechnology (Regular ed.), 2015-04, Vol.33 (4), p.230-236</ispartof><rights>Elsevier Ltd</rights><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Apr 2015</rights><rights>2015 Published by Elsevier Ltd. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c616t-949cc75c21eab6bd2ec5b26bd5730c558f036cac40f9159d6c5913bd98df3d233</citedby><cites>FETCH-LOGICAL-c616t-949cc75c21eab6bd2ec5b26bd5730c558f036cac40f9159d6c5913bd98df3d233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25708906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malik, Ruchi</creatorcontrib><creatorcontrib>Lelkes, Peter I</creatorcontrib><creatorcontrib>Cukierman, Edna</creatorcontrib><title>Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer</title><title>Trends in biotechnology (Regular ed.)</title><addtitle>Trends Biotechnol</addtitle><description>Highlights • Deregulation of ECM (i.e., desmoplastic ECM alignment) alters tumorigenesis. • Both biomechanical and biochemical factors promote desmoplastic ECM formation. • Cell–ECM ‘dynamic reciprocity’ is regulated by integrins and Rho–ROCK.</description><subject>Animals</subject><subject>Behavior</subject><subject>biomechanical and biochemical cues</subject><subject>Biomechanics</subject><subject>Biomedical Research</subject><subject>Breast cancer</subject><subject>Cell Line, Tumor</subject><subject>cell–ECM dynamic reciprocity</subject><subject>Collagen</subject><subject>desmoplasia</subject><subject>Enzymes</subject><subject>extracellular matrix</subject><subject>Extracellular Matrix - chemistry</subject><subject>Extracellular Matrix - metabolism</subject><subject>Genotype &amp; phenotype</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>integrins</subject><subject>Internal Medicine</subject><subject>Mice</subject><subject>Neoplasms - chemistry</subject><subject>Neoplasms - physiopathology</subject><subject>Pancreatic cancer</subject><subject>Physiology</subject><subject>Rho–ROCK</subject><subject>Tumor Microenvironment - physiology</subject><subject>Tumorigenesis</subject><subject>Wound healing</subject><issn>0167-7799</issn><issn>1879-3096</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFUk1v1DAQtRCILgs_ARSJC5eEcRzH8aUIKr6kSkh8nC1nMul6SeJiJ1X773HYpUAvnPz15vm9ecPYUw4FB16_3Beza2fCXVEClwXwAqC6xza8UToXoOv7bJNwKldK6xP2KMY9AAil-UN2UkoFjYZ6wz6_cX5MLHZyaIfMTl3WOo87Gn-dA42-o8FNF5nvszgHP6Zbup6DRRqGZbAhG-0c3HXmpgzthBQeswe9HSI9Oa5b9u3d269nH_LzT-8_nr0-z7Hm9ZzrSiMqiSUn29ZtVxLKtkwbqQSglE0PokaLFfSaS93VKDUXbaebrhddKcSWnR54L5d2pA5pSqoGcxncaMON8daZf18mtzMX_spUogGpmkTw4kgQ_I-F4mxGF1dbdiK_RMPrhpdS66pK0Od3oHu_hCnZSyhVVQ3nSfaWyQMKg48xUH8rhoNZUzN7c0zNrKkZ4Calluqe_e3ktup3TAnw6gCg1M8rR8FEdJSa3blAOJvOu_9-cXqHAVOqa8bf6YbiHzcmlgbMl3V01snhMk1NCUr8BBJ9wco</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Malik, Ruchi</creator><creator>Lelkes, Peter I</creator><creator>Cukierman, Edna</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150401</creationdate><title>Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer</title><author>Malik, Ruchi ; Lelkes, Peter I ; Cukierman, Edna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c616t-949cc75c21eab6bd2ec5b26bd5730c558f036cac40f9159d6c5913bd98df3d233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Behavior</topic><topic>biomechanical and biochemical cues</topic><topic>Biomechanics</topic><topic>Biomedical Research</topic><topic>Breast cancer</topic><topic>Cell Line, Tumor</topic><topic>cell–ECM dynamic reciprocity</topic><topic>Collagen</topic><topic>desmoplasia</topic><topic>Enzymes</topic><topic>extracellular matrix</topic><topic>Extracellular Matrix - chemistry</topic><topic>Extracellular Matrix - metabolism</topic><topic>Genotype &amp; phenotype</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>integrins</topic><topic>Internal Medicine</topic><topic>Mice</topic><topic>Neoplasms - chemistry</topic><topic>Neoplasms - physiopathology</topic><topic>Pancreatic cancer</topic><topic>Physiology</topic><topic>Rho–ROCK</topic><topic>Tumor Microenvironment - physiology</topic><topic>Tumorigenesis</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malik, Ruchi</creatorcontrib><creatorcontrib>Lelkes, Peter I</creatorcontrib><creatorcontrib>Cukierman, Edna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics &amp; Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ANTE: Abstracts in New Technology &amp; Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts – Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Research Library</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Trends in biotechnology (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malik, Ruchi</au><au>Lelkes, Peter I</au><au>Cukierman, Edna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer</atitle><jtitle>Trends in biotechnology (Regular ed.)</jtitle><addtitle>Trends Biotechnol</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>33</volume><issue>4</issue><spage>230</spage><epage>236</epage><pages>230-236</pages><issn>0167-7799</issn><eissn>1879-3096</eissn><abstract>Highlights • Deregulation of ECM (i.e., desmoplastic ECM alignment) alters tumorigenesis. • Both biomechanical and biochemical factors promote desmoplastic ECM formation. • Cell–ECM ‘dynamic reciprocity’ is regulated by integrins and Rho–ROCK.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25708906</pmid><doi>10.1016/j.tibtech.2015.01.004</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0167-7799
ispartof Trends in biotechnology (Regular ed.), 2015-04, Vol.33 (4), p.230-236
issn 0167-7799
1879-3096
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4380578
source ScienceDirect Freedom Collection
subjects Animals
Behavior
biomechanical and biochemical cues
Biomechanics
Biomedical Research
Breast cancer
Cell Line, Tumor
cell–ECM dynamic reciprocity
Collagen
desmoplasia
Enzymes
extracellular matrix
Extracellular Matrix - chemistry
Extracellular Matrix - metabolism
Genotype & phenotype
Homeostasis
Humans
integrins
Internal Medicine
Mice
Neoplasms - chemistry
Neoplasms - physiopathology
Pancreatic cancer
Physiology
Rho–ROCK
Tumor Microenvironment - physiology
Tumorigenesis
Wound healing
title Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T23%3A59%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Biomechanical%20and%20biochemical%20remodeling%20of%20stromal%20extracellular%20matrix%20in%20cancer&rft.jtitle=Trends%20in%20biotechnology%20(Regular%20ed.)&rft.au=Malik,%20Ruchi&rft.date=2015-04-01&rft.volume=33&rft.issue=4&rft.spage=230&rft.epage=236&rft.pages=230-236&rft.issn=0167-7799&rft.eissn=1879-3096&rft_id=info:doi/10.1016/j.tibtech.2015.01.004&rft_dat=%3Cproquest_pubme%3E3660590791%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c616t-949cc75c21eab6bd2ec5b26bd5730c558f036cac40f9159d6c5913bd98df3d233%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1674481157&rft_id=info:pmid/25708906&rfr_iscdi=true