Reduced Slc2a4/GLUT4 expression in subcutaneous adipose tissue of monosodium glutamate obese mice is recovered after atorvastatin treatment

Decreased expression of glucose transporter protein GLUT4, encoded by the solute carrier 2A4 (Slc2a4) gene, is involved in obesity-induced insulin resistance. Local tissue inflammation, by nuclear factor-κB (NFκB)-mediated pathway, has been related to Slc2a4 repression; a mechanism that could be mod...

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Published in:Diabetology and metabolic syndrome 2015-03, Vol.7 (1), p.18-18, Article 18
Main Authors: Poletto, Ana Cláudia, David-Silva, Aline, Yamamoto, Aline Pedro de Melo, Machado, Ubiratan Fabres, Furuya, Daniela Tomie
Format: Article
Language:English
Subjects:
Adipose tissues
Analysis
Dextrose
Dosage and administration
Drug therapy
Genes
Glucose
Glutamate
Health aspects
Inflammation
Insulin
Insulin resistance
Interleukins
Monosodium glutamate
Obesity
RNA
Short Report
Statins
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Summary:Decreased expression of glucose transporter protein GLUT4, encoded by the solute carrier 2A4 (Slc2a4) gene, is involved in obesity-induced insulin resistance. Local tissue inflammation, by nuclear factor-κB (NFκB)-mediated pathway, has been related to Slc2a4 repression; a mechanism that could be modulated by statins. Using a model of obesity with insulin resistance, this study investigated whether (1) inflammatory markers and Slc2a4 expression are altered; (2) atorvastatin has beneficial effects on inflammation and Slc2a4 expression; and (3) inhibitor of NFκB (IKK)/NFκB pathway is involved in subcutaneous adipose tissue (SAT). Obese mice showed insulin resistance, decreased expression of Slc2a4 mRNA (66%, P 
ISSN:1758-5996
1758-5996
DOI:10.1186/s13098-015-0015-6