Albumin rather than C-reactive protein may be valuable in predicting and monitoring the severity and course of acute respiratory distress syndrome in critically ill patients with or at risk for the syndrome after new onset fever

• Published in: BMC pulmonary medicine 2015-03, Vol.15 (1), p.22-22, Article 22
• Main Authors: Hoeboer, Sandra H, Oudemans-van Straaten, Heleen M, Groeneveld, A B Johan
• Format: Article
• Language: English
• Subjects: Acute respiratory distress syndrome; Adult; Aged; Aged, 80 and over; Analysis; Area Under Curve; Biomarkers - metabolism; C-reactive protein; C-Reactive Protein - metabolism; Care and treatment; Cohort Studies; Female; Fever - metabolism; Humans; Intensive Care Units; L-Lactate Dehydrogenase - metabolism; Male; Middle Aged; Prognosis; Prospective Studies; Respiratory Distress Syndrome, Adult - metabolism; Respiratory Distress Syndrome, Adult - mortality; Risk Assessment; Risk factors; ROC Curve; Serum Albumin - metabolism; Severity of Illness Index
• ISSN: 1471-2466; 1471-2466
• DOI: 10.1186/s12890-015-0015-1

We studied the value of routine biochemical variables albumin, C-reactive protein (CRP) and lactate dehydrogenase (LDH) to improve prediction and monitoring of acute respiratory distress syndrome (ARDS) severity in the intensive care unit. In 101 critically ill patients, with or at risk for ARDS after new onset fever, data were collected on days (D) 0, 1, 2, and 7 after inclusion. ARDS was defined by the Berlin definition and lung injury score (LIS). At baseline, 48 patients had mild to severe ARDS according to Berlin and 87 according to LIS (Rs = 0.54, P