Extracellular proteolysis of reelin by tissue plasminogen activator following synaptic potentiation

Highlights • Reelin is important in adult synaptic plasticity and learning and memory. • How reelin is regulated remains to be elucidated. • tPA KO mice do not show alterations in basal reelin levels. • tPA KO mice lack the activity-dependent reelin processing that wild-type mice show. • Reelin is p...

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Bibliographic Details
Published in:Neuroscience 2014-08, Vol.274, p.299-307
Main Authors: Trotter, J.H, Lussier, A.L, Psilos, K.E, Mahoney, H.L, Sponaugle, A.E, Hoe, H.-S, Rebeck, G.W, Weeber, E.J
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Adhesion Molecules, Neuronal - metabolism
Extracellular Matrix Proteins - metabolism
Extracellular Space - metabolism
Fundamental and applied biological sciences. Psychology
HEK293 Cells
Hippocampus
Hippocampus - physiology
Humans
Long-term potentiation
Long-Term Potentiation - drug effects
Long-Term Potentiation - physiology
Male
Mice, Inbred C57BL
Mice, Knockout
Nerve Tissue Proteins - metabolism
Neurology
Potassium Channel Blockers - pharmacology
Proteolysis
Recombinant Proteins - metabolism
Reelin
Serine Endopeptidases - metabolism
Tetraethylammonium - pharmacology
Tetraethylammonium chloride
Tissue Culture Techniques
Tissue plasminogen activator (tPA)
Tissue Plasminogen Activator - genetics
Tissue Plasminogen Activator - metabolism
Vertebrates: nervous system and sense organs
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Summary:Highlights • Reelin is important in adult synaptic plasticity and learning and memory. • How reelin is regulated remains to be elucidated. • tPA KO mice do not show alterations in basal reelin levels. • tPA KO mice lack the activity-dependent reelin processing that wild-type mice show. • Reelin is processed by tPA following chemically induced synaptic activation.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.05.046