Effect of a 3-day high-fat feeding period on carbohydrate balance and ad libitum energy intake in humans

Objective: A reduction in glycogen after the switch to an isoenergetic high-fat diet (HFD) might promote a compensatory increase in food intake to reestablish carbohydrate balance. We assessed the effect of an isoenergetic switch from a 49%-carbohydrate to 50%-fat diet on nutrient balance and ad lib...

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Bibliographic Details
Published in:International Journal of Obesity 2010-05, Vol.34 (5), p.886-891
Main Authors: Galgani, J E, de Jonge, L, Most, M M, Bray, G A, Smith, S R
Format: Article
Language:English
Subjects:
631/443/319/333/1465
631/45/287/1182
631/45/72/1201
Adolescent
Adult
Bioenergetics
Biological and medical sciences
Biomedical research
Carbohydrates
Diet
Dietary Carbohydrates - administration & dosage
Dietary Carbohydrates - metabolism
Dietary Fats - administration & dosage
Dietary Fats - metabolism
Energy
Energy balance
Energy Intake
Energy Metabolism
Epidemiology
Feeding Behavior
Female
Food
Food Preferences
Fruits
Glycogen - metabolism
Health aspects
Health Promotion and Disease Prevention
Humans
Internal Medicine
Ketogenic diet
Male
Medical sciences
Medicine
Medicine & Public Health
Menstruation
Metabolic Diseases
Metabolism
Nutrient balance
Obesity
Obesity - metabolism
original-article
Oxidation
Oxidation-Reduction
Oxygen Consumption
Physiological aspects
Proteins
Public Health
Research centers
Respiration
Time Factors
Young Adult
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Summary:Objective: A reduction in glycogen after the switch to an isoenergetic high-fat diet (HFD) might promote a compensatory increase in food intake to reestablish carbohydrate balance. We assessed the effect of an isoenergetic switch from a 49%-carbohydrate to 50%-fat diet on nutrient balance and ad libitum food intake. We hypothesized that carbohydrate balance would be inversely related to ad libitum energy intake. Methods: In 47 men and 11 women (22.6±0.4 years; 26.1±0.5 kg m –2 ), fuel balance was measured in a respiration chamber over 4 days. During the first day, an isoenergetic, high-carbohydrate diet was provided followed by a 3-day isoenergetic, HFD. At the end of this period and after 16 h of fasting, three options of foods (cookies, fruit salad and turkey sandwich) were offered ad libitum for 4 h. The relationships between post-chamber ad libitum intake and macronutrient oxidation and balance measured day-to-day and over the 4-day respiration chamber stay were studied. Results: After switching to a HFD, 24-h respiratory quotient decreased from 0.87±0.02 to 0.83±0.02 ( P
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2010.16