The Expression and Distributions of ANP32A in the Developing Brain

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A (ANP32A), has multiple functions involved in neuritogenesis, transcriptional regulation, and apoptosis. However, whether ANP32A has an effect on the mammalian developing brain is still in question. In this study, it was shown that brai...

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Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-8
Main Authors: Zhang, Da-Jin, Li, Jin-Feng, Cui, Chunping, Ma, Xiaodong, Wang, Fuyu, Liu, Xinshan, Liu, Xin-Shan, Wang, Yunliang, Wang, Shan-Shan, Shi, Chenghe
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Brain
Brain - cytology
Brain - embryology
Cell Differentiation - physiology
Fetal brain
Gene expression
Gene Expression Regulation, Developmental - physiology
Growth
Humans
Male
Mice
Nervous system
Neurons
Neurons - cytology
Neurons - metabolism
Nuclear Proteins - biosynthesis
Phosphoproteins
Physiological aspects
Proteins
Rodents
Signal transduction
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Summary:Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A (ANP32A), has multiple functions involved in neuritogenesis, transcriptional regulation, and apoptosis. However, whether ANP32A has an effect on the mammalian developing brain is still in question. In this study, it was shown that brain was the organ that expressed the most abundant ANP32A by human multiple tissue expression (MTE) array. The distribution of ANP32A in the different adult brain areas was diverse dramatically, with high expression in cerebellum, temporal lobe, and cerebral cortex and with low expression in pons, medulla oblongata, and spinal cord. The expression of ANP32A was higher in the adult brain than in the fetal brain of not only humans but also mice in a time-dependent manner. ANP32A signals were dispersed accordantly in embryonic mouse brain. However, ANP32A was abundant in the granular layer of the cerebellum and the cerebral cortex when the mice were growing up, as well as in the Purkinje cells of the cerebellum. The variation of expression levels and distribution of ANP32A in the developing brain would imply that ANP32A may play an important role in mammalian brain development, especially in the differentiation and function of neurons in the cerebellum and the cerebral cortex.
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/207347