Dopaminergic Modulation of Synaptic Transmission in Cortex and Striatum

Among the many neuromodulators used by the mammalian brain to regulate circuit function and plasticity, dopamine (DA) stands out as one of the most behaviorally powerful. Perturbations of DA signaling are implicated in the pathogenesis or exploited in the treatment of many neuropsychiatric diseases,...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2012-10, Vol.76 (1), p.33-50
Main Authors: Tritsch, Nicolas X., Sabatini, Bernardo L.
Format: Article
Language:English
Subjects:
Animals
Brain
Brain - physiology
Circuits
Cortex (prefrontal)
Dopamine
Dopamine - metabolism
Excitability
Gilles de la Tourette syndrome
Humans
Influence
Integration
Kinases
Mental disorders
Movement disorders
Neostriatum
Neurodegenerative diseases
Neuromodulation
Neurons
Neurons - metabolism
Obsessive compulsive disorder
Parkinson's disease
Plasticity (synaptic)
Protein transport
Schizophrenia
Studies
Synaptic transmission
Synaptic Transmission - physiology
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Summary:Among the many neuromodulators used by the mammalian brain to regulate circuit function and plasticity, dopamine (DA) stands out as one of the most behaviorally powerful. Perturbations of DA signaling are implicated in the pathogenesis or exploited in the treatment of many neuropsychiatric diseases, including Parkinson’s disease (PD), addiction, schizophrenia, obsessive compulsive disorder, and Tourette’s syndrome. Although the precise mechanisms employed by DA to exert its control over behavior are not fully understood, DA is known to regulate many electrical and biochemical aspects of neuronal function including excitability, synaptic transmission, integration and plasticity, protein trafficking, and gene transcription. In this Review, we discuss the actions of DA on ionic and synaptic signaling in neurons of the prefrontal cortex and striatum, brain areas in which dopaminergic dysfunction is thought to be central to disease. Dopamine (DA) regulates many aspects of neuronal function. In this Review, Tritsch and Sabatini discuss the actions of DA on neuronal signaling in the prefrontal cortex and striatum, brain areas in which dopaminergic dysfunction is thought to be central to disease.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2012.09.023