Minnelide reduces tumor burden in preclinical models of osteosarcoma

Highlights • Triptolide induces significant apoptosis in osteosarcoma cell lines with minimal effect on osteoblast cells. • Triptolide downregulates multiple pro-survival genes and pathways that contribute to osteosarcoma progression. • Minnelide reduces tumor burden in orthotopic model of osteosarc...

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Bibliographic Details
Published in:Cancer letters 2013-07, Vol.335 (2), p.412-420
Main Authors: Banerjee, Sulagna, Thayanithy, Venugopal, Sangwan, Veena, Mackenzie, Tiffany N, Saluja, Ashok K, Subramanian, Subbaya
Format: Article
Language:English
Subjects:
adolescents
Animals
Antibiotics
Antineoplastic Agents, Alkylating - pharmacology
apoptosis
Apoptosis - drug effects
Cancer therapies
Caspase 3 - metabolism
Caspase 7 - metabolism
Caspase 9 - metabolism
Cell growth
Cell Line, Tumor
Cell Survival - drug effects
children
Diterpenes - pharmacology
Down-Regulation
drugs
Epoxy Compounds - pharmacology
Female
Gene Expression Regulation, Neoplastic - drug effects
Heat shock proteins
Heat-Shock Proteins - biosynthesis
Hematology, Oncology and Palliative Medicine
Humans
Inhibitor of Apoptosis Proteins - biosynthesis
Lung Neoplasms - drug therapy
Lung Neoplasms - secondary
Medical prognosis
Metastasis
Mice
Mice, Nude
Minnelide
Neoplasm Transplantation
NF-kappa B - metabolism
NF-κB
Organophosphates - pharmacology
Osteoblasts - drug effects
Osteosarcoma
Osteosarcoma - drug therapy
Phenanthrenes - pharmacology
Proto-Oncogene Proteins c-myc - biosynthesis
R&D
Research & development
survival rate
Survivin
Triptolide
Tumor Burden - drug effects
Xenograft Model Antitumor Assays
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Summary:Highlights • Triptolide induces significant apoptosis in osteosarcoma cell lines with minimal effect on osteoblast cells. • Triptolide downregulates multiple pro-survival genes and pathways that contribute to osteosarcoma progression. • Minnelide reduces tumor burden in orthotopic model of osteosarcoma. • Minnelide decreases metastasis in lung colonization model.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.02.050