Efficacy of linezolid, teicoplanin, and vancomycin in prevention of an experimental polytetrafluoroethylene graft infection model caused by methicillin-resistant Staphylococcus aureus

The aim of this study was to evaluate the effectiveness of linezolid, teicoplanin, and vancomycin in prevention of prosthetic vascular graft infections in a vascular graft infection model. Fifty rats were divided into 5 groups. A polytetrafluoroethylene graft was implanted on the back of each rat. M...

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Bibliographic Details
Published in:Medical science monitor 2015-03, Vol.21, p.909-914
Main Authors: Mese, Bulent, Bozoglan, Orhan, Elveren, Serdal, Eroglu, Erdinc, Gul, Mustafa, Celik, Ahmet, Ciralik, Harun, Yildirimdemir, Halil Ibrahim, Yasim, Alptekin
Format: Article
Language:English
Subjects:
Animal Study
Animals
C-Reactive Protein - metabolism
Disease Models, Animal
Leukocytes - pathology
Linezolid - pharmacology
Linezolid - therapeutic use
Male
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - physiology
Polytetrafluoroethylene - adverse effects
Prealbumin - metabolism
Prosthesis-Related Infections - drug therapy
Prosthesis-Related Infections - microbiology
Prosthesis-Related Infections - pathology
Prosthesis-Related Infections - prevention & control
Rats, Wistar
Teicoplanin - pharmacology
Teicoplanin - therapeutic use
Treatment Outcome
Vancomycin - pharmacology
Vancomycin - therapeutic use
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Summary:The aim of this study was to evaluate the effectiveness of linezolid, teicoplanin, and vancomycin in prevention of prosthetic vascular graft infections in a vascular graft infection model. Fifty rats were divided into 5 groups. A polytetrafluoroethylene graft was implanted on the back of each rat. Methicillin-resistant Staphylococcus aureus (MRSA) strain was inoculated into all rats except Group 1. Group 2 was not given any treatment, Group 3 received linezolid, Group 4 received vancomycin, and Group 5 received teicoplanin. The grafts were removed for microbiological and histological examinations on the 7th day. In addition, C-reactive protein and prealbumin levels and leukocyte counts in obtained blood specimens were determined. Group 1 did not have infection. Group 2 had bacteria 5.7 × 10(4) CFU/cm(2). Group 3 and Group 4 had less bacterial growth. Group 5 had no bacterial growth. The number of bacteria was significantly higher in Group 2 than in the other experimental groups and the control group (p
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.893098