Functional magnetic resonance imaging of intrinsic brain networks for translational drug discovery

Highlights • Task-independent fMRI holds great promise for translational drug discovery. • Analogous methods can be used across species to examine intrinsic brain networks. • The utility of the approach in schizophrenia research is discussed.

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2014-08, Vol.35 (8), p.397-403
Main Authors: Smucny, Jason, Wylie, Korey P, Tregellas, Jason R
Format: Article
Language:English
Subjects:
Advanced Basic Science
Animals
biomarker
Brain Mapping - methods
connectivity
graph theory
Humans
Magnetic Resonance Imaging - methods
neuroimaging
resting state
schizophrenia
Schizophrenia - physiopathology
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Description
Summary:Highlights • Task-independent fMRI holds great promise for translational drug discovery. • Analogous methods can be used across species to examine intrinsic brain networks. • The utility of the approach in schizophrenia research is discussed.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2014.05.001