Similarities and Differences in Gastrointestinal Physiology Between Neonates and Adults: a Physiologically Based Pharmacokinetic Modeling Perspective

Physiologically based pharmacokinetic (PBPK) modeling holds great promise for anticipating the quantitative changes of pharmacokinetics in pediatric populations relative to adults, which has served as a useful tool in regulatory reviews. Although the availability of specialized software for PBPK mod...

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Bibliographic Details
Published in:The AAPS journal 2014-11, Vol.16 (6), p.1162-1166
Main Authors: Yu, Guo, Zheng, Qing-Shan, Li, Guo-Fu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aging - physiology
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Child
Child, Preschool
Commentary
Gastrointestinal Absorption - physiology
Gastrointestinal Tract - growth & development
Gastrointestinal Tract - metabolism
Gastrointestinal Tract - physiology
Gastrointestinal Transit - physiology
Humans
Hydrogen-Ion Concentration
Infant
Infant, Newborn
Models, Biological
Pharmacology/Toxicology
Pharmacy
Young Adult
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Summary:Physiologically based pharmacokinetic (PBPK) modeling holds great promise for anticipating the quantitative changes of pharmacokinetics in pediatric populations relative to adults, which has served as a useful tool in regulatory reviews. Although the availability of specialized software for PBPK modeling has facilitated the widespread applications of this approach in regulatory submissions, challenges in the implementation and interpretation of pediatric PBPK models remain great, for which controversies and knowledge gaps remain regarding neonatal development of the gastrointestinal tract. The commentary highlights the similarities and differences in the gastrointestinal pH and transit time between neonates and adults from a PBPK modeling prospective. Understanding the similarities and differences in these physiological parameters governing oral absorption would promote good practice in the use of pediatric PBPK modeling to assess oral exposure and pharmacokinetics in neonates.
ISSN:1550-7416
1550-7416
DOI:10.1208/s12248-014-9652-1