Vascular Function, Cerebral Cortical Thickness, and Cognitive Performance in Middle‐Aged Hispanic and Non‐Hispanic Caucasian Adults

Hispanics are at increased risk for acquiring cardiovascular risk factors that contribute to cognitive dysfunction. To compare indices of vascular health with measures of cerebral gray matter integrity, 60 middle‐aged Hispanic and non‐Hispanic Caucasian participants were matched across age, sex, yea...

Full description

Saved in:
Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2015-04, Vol.17 (4), p.306-312
Main Authors: Pasha, Evan P., Kaur, Sonya S., Gonzales, Mitzi M., Machin, Daniel R., Kasischke, Kennon, Tanaka, Hirofumi, Haley, Andreana P.
Format: Article
Language:English
Subjects:
Adult
Cardiovascular Diseases - ethnology
Cardiovascular Diseases - etiology
Cerebral Cortex - pathology
Cognition
Cognition Disorders - ethnology
Female
Hispanic or Latino
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Original Paper
Original Papers
Risk Assessment
Risk Factors
Vascular Stiffness
White People
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hispanics are at increased risk for acquiring cardiovascular risk factors that contribute to cognitive dysfunction. To compare indices of vascular health with measures of cerebral gray matter integrity, 60 middle‐aged Hispanic and non‐Hispanic Caucasian participants were matched across age, sex, years of education, and mental status. Arterial stiffness was characterized by β‐stiffness index and carotid‐femoral pulse wave velocity, and magnetic resonance imaging estimated cortical thickness in a priori regions of interest known to be susceptible to vascular risk factors. Measures of arterial stiffness were significantly higher in Hispanics than in non‐Hispanic Caucasians. Hispanics exhibited thinner left inferior frontal gyrus (LIFG) cortical thickness (P=.04) with concurrently lower language (P=.02), memory (P=.03), and attention‐executive functioning (P=.02). These results suggest that compromised vascular health may occur simultaneously with cortical thinning of the LIFG as an early neuropathological alteration in Hispanics.
ISSN:1524-6175
1751-7176
1751-7176
DOI:10.1111/jch.12512