Organic Carbamates in Drug Design and Medicinal Chemistry

The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many derivatives are specifically designed to make drug–target interactions through their carbamate moiety. In this Perspective, we present propertie...

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Bibliographic Details
Published in:Journal of medicinal chemistry 2015-04, Vol.58 (7), p.2895-2940
Main Authors: Ghosh, Arun K, Brindisi, Margherita
Format: Article
Language:English
Subjects:
Amyloid Precursor Protein Secretases - antagonists & inhibitors
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Carbamates - chemical synthesis
Carbamates - chemistry
Carbamates - pharmacology
Chemistry Techniques, Synthetic
Chemistry, Pharmaceutical - methods
Cysteine Proteinase Inhibitors - chemistry
Cysteine Proteinase Inhibitors - pharmacology
Drug Design
Drug Stability
Hepatitis C - drug therapy
HIV Protease
HIV Protease Inhibitors - chemistry
HIV Protease Inhibitors - pharmacology
Humans
Prodrugs - chemical synthesis
Serine Proteinase Inhibitors - chemistry
Serine Proteinase Inhibitors - pharmacology
Viral Nonstructural Proteins - antagonists & inhibitors
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Summary:The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many derivatives are specifically designed to make drug–target interactions through their carbamate moiety. In this Perspective, we present properties and stabilities of carbamates, reagents and chemical methodologies for the synthesis of carbamates, and recent applications of carbamates in drug design and medicinal chemistry.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm501371s