Tissue-engineered lymphatic graft for the treatment of lymphedema

Abstract Background Lymphedema is a chronic debilitating condition and curative treatment is yet to be found. Tissue engineering approach, which combines cellular components, scaffold, and molecular signals hold great potential in the treatment of secondary lymphedema with the advent of lymphatic gr...

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Bibliographic Details
Published in:The Journal of surgical research 2014-12, Vol.192 (2), p.544-554
Main Authors: Kanapathy, Muholan, MD, Patel, Nikhil M., MRCS, MSc, Kalaskar, Deepak M., PhD, Mosahebi, Afshin, FRCS (Plast), PhD, MBA, Mehrara, Babak J., MD, Seifalian, Alexander M., PhD
Format: Article
Language:English
Subjects:
Humans
Lymphatic graft
Lymphatic regeneration
Lymphatic Vessels - physiology
Lymphatic Vessels - transplantation
Lymphedema
Lymphedema - surgery
Lymphedema - therapy
Nanotechnology
Nanotechnology - methods
Regeneration
Surgery
Tissue engineering
Tissue Engineering - methods
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Summary:Abstract Background Lymphedema is a chronic debilitating condition and curative treatment is yet to be found. Tissue engineering approach, which combines cellular components, scaffold, and molecular signals hold great potential in the treatment of secondary lymphedema with the advent of lymphatic graft to reconstruct damaged collecting lymphatic vessel. This review highlights the ideal characteristics of lymphatic graft, the limitation and challenges faced, and the approaches in developing tissue-engineered lymphatic graft. Methods Literature on tissue engineering of lymphatic system and lymphatic tissue biology was reviewed. Results The prime challenge in the design and manufacturing of this graft is producing endothelialized conduit with intraluminal valves. Suitable scaffold material is needed to ensure stability and functionality of the construct. Endothelialization of the construct can be enhanced via biofunctionalization and nanotopography, which mimics extracellular matrix. Nanocomposite polymers with improved performance over existing biomaterials are likely to benefit the development of lymphatic graft. Conclusions With the in-depth understanding of tissue engineering, nanotechnology, and improved knowledge on the biology of lymphatic regeneration, the aspiration to develop successful lymphatic graft is well achievable.
ISSN:0022-4804
1095-8673
DOI:10.1016/j.jss.2014.07.059