Osteoarthritis in the XXIst century: risk factors and behaviours that influence disease onset and progression

Osteoarthritis (OA) is a growing public health problem across the globe, affecting more than half of the over 65 population. In the past, OA was considered a wear and tear disease, leading to the loss of articular cartilage and joint disability. Nowadays, thanks to advancements in molecular biology,...

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Bibliographic Details
Published in:International journal of molecular sciences 2015-03, Vol.16 (3), p.6093-6112
Main Authors: Musumeci, Giuseppe, Aiello, Flavia Concetta, Szychlinska, Marta Anna, Di Rosa, Michelino, Castrogiovanni, Paola, Mobasheri, Ali
Format: Article
Language:English
Subjects:
Arthritis
Cartilage
Cartilage, Articular - metabolism
Cartilage, Articular - pathology
Diet
Disease management
Disease Progression
Epigenesis, Genetic
Health risk assessment
Humans
Life Style
Motor Activity
Osteoarthritis - genetics
Osteoarthritis - metabolism
Osteoarthritis - pathology
Reactive Oxygen Species - metabolism
Review
Risk Factors
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Summary:Osteoarthritis (OA) is a growing public health problem across the globe, affecting more than half of the over 65 population. In the past, OA was considered a wear and tear disease, leading to the loss of articular cartilage and joint disability. Nowadays, thanks to advancements in molecular biology, OA is believed to be a very complex multifactorial disease. OA is a degenerative disease characterized by "low-grade inflammation" in cartilage and synovium, resulting in the loss of joint structure and progressive deterioration of cartilage. Although the disease can be dependent on genetic and epigenetic factors, sex, ethnicity, and age (cellular senescence, apoptosis and lubricin), it is also associated with obesity and overweight, dietary factors, sedentary lifestyle and sport injuries. The aim of this review is to highlight how certain behaviors, habits and lifestyles may be involved in the onset and progression of OA and to summarize the principal risk factors involved in the development of this complicated joint disorder.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms16036093