Rabies vaccine preserved by vaporization is thermostable and immunogenic

Highlights • Rabies virus vaccine was preserved by vaporization. • Vaccine remained stable for at least 23 months at 22 °C. • Antigen content in inactivated vaccine was similar to a commercial rabies vaccine. • Attenuated and inactivated vaccines induced rabies virus neutralizing antibodies. • Both...

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Bibliographic Details
Published in:Vaccine 2015-05, Vol.33 (19), p.2203-2206
Main Authors: Smith, Todd G, Siirin, Marina, Wu, Xianfu, Hanlon, Cathleen A, Bronshtein, Victor
Format: Article
Language:English
Subjects:
Allergy and Immunology
ambient temperature
Animals
Antibodies
Antigens
Cold storage
dogs
Drug Stability
Efficacy
enzootic diseases
Female
foams
Humans
Immunogenicity
Irradiation
Lyssavirus
Mice
Microbial Viability
mortality
neutralization
neutralizing antibodies
Preservation by vaporization
Rabies
Rabies lyssavirus
Rabies Vaccines - immunology
Rabies virus
Rabies virus - physiology
Radiation
Stability
Temperature
thermal stability
Time Factors
Tropical environment
Tropical environments
tropics
Vaccines
Vaccines, Attenuated - immunology
Vaporization
Viability
Viral Load
Viruses
Volatilization
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Summary:Highlights • Rabies virus vaccine was preserved by vaporization. • Vaccine remained stable for at least 23 months at 22 °C. • Antigen content in inactivated vaccine was similar to a commercial rabies vaccine. • Attenuated and inactivated vaccines induced rabies virus neutralizing antibodies. • Both formulations protected mice from rabies virus challenge.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.03.025