Comparison of Intravoxel Incoherent Motion Diffusion-Weighted MR Imaging and Arterial Spin Labeling MR Imaging in Gliomas

Gliomas grading is important for treatment plan; we aimed to investigate the application of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in gliomas grading, by comparing with the three-dimensional pseudocontinuous arterial spin labeling (3D pCASL). 24 patients (13 high grade...

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Bibliographic Details
Published in:BioMed research international 2015-01, Vol.2015 (2015), p.1-10
Main Authors: Zhang, Zongjun, Zhang, Zhongping, Zhou, Zhenyu, Xu, Qiang, Zhang, Zhiqiang, Li, Jianrui, Lin, Yuankai, Zhang, Yong
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Brain cancer
Brain Neoplasms - blood supply
Brain Neoplasms - physiopathology
Cancer
Cerebrovascular Circulation
Comparative analysis
Diagnosis
Diffusion Magnetic Resonance Imaging
Female
Glioma - blood supply
Glioma - physiopathology
Gliomas
Humans
Magnetic resonance imaging
Male
Medical imaging
Middle Aged
Motion
Neoplasm Grading
Pathology
ROC Curve
Spin Labels
Tumors
White Matter - pathology
Young Adult
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Summary:Gliomas grading is important for treatment plan; we aimed to investigate the application of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in gliomas grading, by comparing with the three-dimensional pseudocontinuous arterial spin labeling (3D pCASL). 24 patients (13 high grade gliomas and 11 low grade gliomas) underwent IVIM DWI and 3D pCASL imaging before operation; maps of fast diffusion coefficient (D∗), slow diffusion coefficient (D), fractional perfusion-related volume (f), and apparent diffusion coefficient (ADC) as well as cerebral blood flow (CBF) were calculated and then coregistered to generate the corresponding parameter values. We found CBF and D∗ were higher in the high grade gliomas, whereas ADC, D, and f were lower (all P0.05). IVIM DWI showed more efficiency than 3D pCASL but less validity than conventional DWI in differentiating the high from low grade gliomas.
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/234245